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CDPPB
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很棒纯度: 99.16%
货号 T22641Cas号 781652-57-1
CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
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CDPPB
一键复制产品信息 很棒纯度: 99.16%
货号 T22641Cas号 781652-57-1
CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 365 | 现货 | |
| 5 mg | ¥ 828 | 现货 | |
| 10 mg | ¥ 1,320 | 现货 | |
| 25 mg | ¥ 2,430 | 现货 | |
| 50 mg | ¥ 3,980 | 现货 | |
| 100 mg | ¥ 5,530 | 现货 | |
| 200 mg | ¥ 7,570 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 663 | 现货 |
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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
CDPPB AI Summary
CDPPB has been shown to potentiate the activity of human and rat metabotropic glutamate receptor 5 (mGluR5), demonstrating a fold potentiation of 4.0 in CHO cells overexpressing human mGluR5 and 4.3 towards rat mGluR5. It exhibits EC50 values of 10.0 nM for human mGluR5 and 20.0 nM for rat mGluR5 in transfected CHO cells. Additionally, its Ki value for human mGluR5 is 250.0 nM in a displacement assay. The compound shows positive allosteric modulation in calcium mobilization assays with EC50 values of 177.83 nM and 98.0 nM for human and rat mGluR5, respectively, in HEK293 cells. CDPPB demonstrates a LogD7.4 value of 3.82, suggesting favorable lipophilicity and membrane permeability.
Moreover, CDPPB exhibits antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at a 10 µM concentration, with inhibition rates of 0.24% and 0.53%, respectively. It also exhibits an inhibitory effect on the SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 5.339%. Inhibition of human HDAC6 was observed with percentages of 69.99% and 12.17% using different peptide substrates.
Thermally, CDPPB affects various protein domain stabilities, increasing stability of domains such as S229-K512 and M626-G746, while decreasing stability of others like N44-E168 and M1-K294. Furthermore, the compound shows a range of effects on GPCR targets in beta-arrestin recruitment assays, inhibiting targets like FPR2 and ADRB2, while activating receptors such as C5AR1 and S1PR1. These diverse bioactivities suggest it may modulate multiple physiological processes regulated by these receptors..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). |
| 靶点活性 | mGluR5:27 nM (EC50) |
| 分子量 | 364.4 |
| 分子式 | C23H16N4O |
| CAS No. | 781652-57-1 |
| Smiles | O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N |
| 密度 | 1.203g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 3.65 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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