IL-17RD Protein, Human, Recombinant (hFc)

Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

规格	价格/CNY		数量
10 μg	￥ 680	5日内发货
50 μg	￥ 2,060	5日内发货
500 μg	￥ 12,400	5日内发货
1 mg	￥ 18,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 680

5日内发货

50 μg

￥ 2,060

5日内发货

500 μg

￥ 12,400

5日内发货

1 mg

￥ 18,700

5日内发货

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q8NFM7
别名	IL17Rhom, IL17RD, IL-17RD, IL-17 RD, IL17RLM, SEF, interleukin 17 receptor D, IL-17RDIL-17 receptor D
氨基酸序列	Cys17-Arg299
蛋白构建	Cys17-Arg299
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	75-90 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

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IL-17RD Protein, Human, Recombinant (hFc)

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