Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发,从而增加 fMLF 刺激的 ROS 产生。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 795 | 现货 | ||
5 mg | ¥ 1,930 | 现货 | ||
10 mg | ¥ 2,890 | 现货 | ||
25 mg | ¥ 4,780 | 现货 | ||
50 mg | ¥ 6,830 | 现货 | ||
100 mg | ¥ 9,270 | 现货 | ||
500 mg | ¥ 18,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,990 | 现货 |
产品描述 | CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. |
体外活性 | CL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils[1]. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells[3]. |
体内活性 | in NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (∼25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone[2]. |
别名 | CL097 |
分子量 | 242.28 |
分子式 | C13H14N4O |
CAS No. | 1026249-18-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95mg/mL (392.11 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.1275 mL | 20.6373 mL | 41.2746 mL | 103.1864 mL |
5 mM | 0.8255 mL | 4.1275 mL | 8.2549 mL | 20.6373 mL | |
10 mM | 0.4127 mL | 2.0637 mL | 4.1275 mL | 10.3186 mL | |
20 mM | 0.2064 mL | 1.0319 mL | 2.0637 mL | 5.1593 mL | |
50 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0637 mL | |
100 mM | 0.0413 mL | 0.2064 mL | 0.4127 mL | 1.0319 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CL097 1026249-18-2 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species TLR Immunological CL-097 inhibit Oligonucleotide Toll-like Receptor (TLR) Peptide TLR7 Heterocycle modulators Inhibitor CL 097 TLR8 inhibitor