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8-Hydroxy-DPAT hydrobromide

Name: 8-Hydroxy-DPAT hydrobromide
Brand: TargetMol
SKU: T22534
Price: 185 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 8-OH-DPAT hydrobromide, 7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐

货号 T22534Cas号 76135-31-4 一键复制产品信息纯度: 99.99%

很棒

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种选择性5-HT1A 激动剂，pIC50为 8.19。它对 5-HT1结合位点的亚型有近 1000 倍的选择性。

8-Hydroxy-DPAT hydrobromide

一键复制产品信息

很棒

纯度: 99.99%

货号 T22534Cas号 76135-31-4

别名 8-OH-DPAT hydrobromide, 7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种选择性5-HT1A 激动剂，pIC50为 8.19。它对 5-HT1结合位点的亚型有近 1000 倍的选择性。

规格	价格	库存
1 mg	¥ 185	现货
5 mg	¥ 398	现货
10 mg	¥ 663	现货
25 mg	¥ 1,390	现货
50 mg	¥ 2,570	现货
100 mg	¥ 3,870	现货
500 mg	¥ 8,530	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.96%

颜色: 白色至灰色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

8-Hydroxy-DPAT hydrobromide AI Summary

8-Hydroxy-DPAT hydrobromide exhibits high binding affinity at the 5-hydroxytryptamine 1A receptor, displacing [3H]8-OH-DPAT in rat brain with a Ki value of 3.18 nM, and shows potent dose-dependent effects with an ED50 value of 0.00006 mg/kg for reducing 5-HTP formation in the rat brain's limbic and striatal regions. It induces hypothermia in both Albino Swiss and CD1 mice with notable dose-dependent effects over various time points and displays antidepressant-like activity by reducing immobility time in the forced swimming test. The hypothermic effect is partially counteracted by the 5-HT1A antagonist WAY 100635. Additionally, the compound shows anxiolytic properties in Sprague-Dawley rats, increasing time spent in the open arm of the Elevated Plus Maze (EPM) test at a dose of 0.5 mg/kg. 8-Hydroxy-DPAT hydrobromide is a potent inhibitor of Bloom's syndrome helicase (BLM) with a potency of 223.9 nM and histone lysine methyltransferase G9a with a potency of 22.4 nM. It also serves as a moderate inhibitor of glutaminase (GLS) with a potency of 11220.2 nM and shows activity against Marburg Virus entry with a potency of 35481.3 nM. Despite showing some activity as an agonist of the mouse serotonin receptor 2A, it demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM and by inhibiting SARS-CoV-2 3CL-Pro protease by 13.03% at 20 µM. In pharmacokinetics, 8-Hydroxy-DPAT hydrobromide has a half-life of 0.45 hours in Sprague-Dawley rat plasma when administered orally at a dose of 10 mg/kg..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.
别名	8-OH-DPAT hydrobromide, 7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐

化学信息

分子量	328.29
分子式	C₁₆H₂₆BrNO
CAS No.	76135-31-4
Smiles	Br.CCCN(CCC)C1CCc2cccc(O)c2C1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: Soluble

DMSO: 50 mg/mL (152.3 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0461 mL	15.2304 mL	30.4609 mL	152.3044 mL
5 mM	0.6092 mL	3.0461 mL	6.0922 mL	30.4609 mL
10 mM	0.3046 mL	1.5230 mL	3.0461 mL	15.2304 mL
20 mM	0.1523 mL	0.7615 mL	1.5230 mL	7.6152 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0461 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	1.5230 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Serotonin Receptor Inhibitor inhibit 8-OH-DPAT Hydrobromide 8-Hydroxy-DPAT Hydrobromide 8HydroxyDPAT hydrobromide 8 Hydroxy DPAT hydrobromide 5-hydroxytryptamine Receptor 5HTReceptor 5-HT1A 5-HT Receptor 5HT Receptor

8-Hydroxy-DPAT hydrobromide

8-Hydroxy-DPAT hydrobromide