ATIC-IN-1 acetate

Name: ATIC-IN-1 acetate
Brand: TargetMol
SKU: T78159
Price: 557 CNY
Availability: InStock
Rating: 5 (10 reviews)

还可以

产品编号 T78159

别名 ATIC 抑制剂 1 醋酸盐

ATIC-IN-1 acetate 是一种氨基咪唑甲酰胺核糖核苷酸转化酶/肌苷一磷酸环化水解酶 (ATIC) 抑制剂，具有潜在的抗肿瘤活性，通过扰动 ATIC 同源二聚化来抑制 AICAR Tfase。

ATIC-IN-1 acetate

还可以

纯度: 99.89%

产品编号 T78159 别名 ATIC 抑制剂 1 醋酸盐

规格	价格	库存
1 mg	¥ 557	In stock
5 mg	¥ 1,360	In stock
10 mg	¥ 2,190	In stock
25 mg	¥ 3,920	In stock
50 mg	¥ 5,690	In stock
1 mL x 10 mM (in DMSO)	¥ 1,570	In stock

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ATIC-IN-1 acetate 相关产品

产品介绍

生物活性

产品描述	ATIC-IN-1 acetate is an inhibitor of aminoimidazole-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) with potential anti-tumor activity. It inhibits AICAR Tfase by disrupting ATIC homo-dimerization.
靶点活性	aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC):685 nM （Ki）
体外活性	ATIC-IN-1 acetate (化合物 14) 是一种氨基咪唑甲酰胺核糖核苷酸转化酶/肌苷一磷酸环化水解酶 (ATIC) 二聚化的抑制剂，其 Ki 值为 685 nM。[1] ATIC-IN-1 acetate（100-500 μM，处理48小时）能够阻碍 MCF-7 细胞的增殖。[1] ATIC-IN-1 acetate（250 μM，作用24-72小时）会减少细胞分裂，而非增加细胞死亡率。[1]
别名	ATIC 抑制剂 1 醋酸盐

化学信息

分子量	523.59
分子式	C₂₃H₃₇N₇O₇
Smiles	O=[N+](C1=CC=C(C[C@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C(N(CC)CC)=O)C=C1)[O-].CC(O)=O

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 40.00 mg/mL (76.40 mM), Sonication is recommended.

DMSO: 40.00 mg/mL (76.40 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9099 mL	9.5495 mL	19.0989 mL	95.4946 mL
5 mM	0.3820 mL	1.9099 mL	3.8198 mL	19.0989 mL
10 mM	0.1910 mL	0.9549 mL	1.9099 mL	9.5495 mL
20 mM	0.0955 mL	0.4775 mL	0.9549 mL	4.7747 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9099 mL