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Temoporfin

Name: Temoporfin
Brand: TargetMol
SKU: T17035
Price: 816 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.71%

货号 T17035Cas号 122341-38-2

别名 替莫卟吩, 替莫泊芬

Temoporfin 能够用于头颈部鳞状细胞癌的光动力学研究。

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Temoporfin

一键复制产品信息

很棒

纯度: 99.71%

货号 T17035 别名 替莫卟吩, 替莫泊芬Cas号 122341-38-2

Temoporfin 能够用于头颈部鳞状细胞癌的光动力学研究。

规格	价格	库存
1 mg	¥ 816	现货
2 mg	¥ 1,180	现货
5 mg	¥ 1,830	现货
10 mg	¥ 3,160	现货
25 mg	¥ 5,200	现货
50 mg	¥ 7,350	现货
100 mg	¥ 9,890	待询
1 mL x 10 mM (in DMSO)	¥ 2,730	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

Temoporfin AI Summary

Temoporfin demonstrates various bioactivities and physicochemical properties. It has a drug level ratio of 3.0 in tumor to skin in iv dosed BDXI rats implanted with rat LSBD1 cells after 24 hours. The compound is soluble in 25% aqueous ethanolic medium at 25°C with a solubility of 600000.0 nM. It exhibits significant antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 cells by 85.92% at 10 µM, and has a 30.74% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. In VERO-6 cells, it shows a 2.08% inhibition rate at 10 µM after 48 hours against SARS-CoV-2. Additionally, Temoporfin has photodynamic antibacterial activity against Enterococcus faecalis at 10 µM and 30 µM concentrations under light irradiation, with log(activity) values of 5.8 and 6.7, respectively. It displays both photodynamic cytotoxicity and dark toxicity against human A549 cells and Enterococcus faecalis. In human QBC939 cells, it shows dark toxicity with a TC50 of 6.08 µM and phototoxic effects upon 650 nm laser irradiation in QBC939 cell xenografts in mice, reducing tumor weight by 35%. The compound also demonstrates phototoxic effects against human HT-29 cells, human MDA-MB-231, mouse 4T1, and HUVEC cells, with varying IC50 values. It is a potent HDAC6 inhibitor, with inhibition percentages of 36.91% and 2.63% using different substrates. Moreover, it shows antiviral activity against West Nile virus, Zika virus, and DENV2, with EC50 values of 10.0 nM, 22.0 nM, and 20.0 nM, respectively. Additionally, it exhibits cytotoxicity against human A549 cells with a CC50 of 40700.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.
别名	替莫卟吩, 替莫泊芬

化学信息

分子量	680.75
分子式	C₄₄H₃₂N₄O₄
CAS No.	122341-38-2
Smiles	Oc1cccc(c1)-c1c2CCc(n2)c(-c2cccc(O)c2)c2ccc([nH]2)c(-c2cccc(O)c2)c2ccc(n2)c(-c2cccc(O)c2)c2ccc1[nH]2
密度	1.386 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27 mg/mL (39.66 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4690 mL	7.3448 mL	14.6897 mL	73.4484 mL
5 mM	0.2938 mL	1.4690 mL	2.9379 mL	14.6897 mL
10 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3448 mL
20 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL