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Haloperidol decanoate

Name: Haloperidol decanoate
Brand: TargetMol
SKU: T25487
Price: 169 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.72%

货号 T25487Cas号 74050-97-8

别名 Neoperidole, KD-136, KD 16, KD 136, Haldol

Haloperidol decanoate (KD 16) 是一种典型的抗精神病药物，用作精神分裂症和情绪障碍的维持治疗，配制成用于肌肉注射的酯。

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Haloperidol decanoate

一键复制产品信息

很棒

纯度: 99.72%

货号 T25487 别名 Neoperidole, KD-136, KD 16, KD 136, HaldolCas号 74050-97-8

Haloperidol decanoate (KD 16) 是一种典型的抗精神病药物，用作精神分裂症和情绪障碍的维持治疗，配制成用于肌肉注射的酯。

规格	价格	库存
1 mg	¥ 169	现货
5 mg	¥ 372	现货
10 mg	¥ 591	现货
25 mg	¥ 1,220	现货
50 mg	¥ 1,820	现货
100 mg	¥ 2,590	现货
200 mg	¥ 3,780	现货
1 mL x 10 mM (in DMSO)	¥ 433	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.57%

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COA HNMR LCMS 产品操作手册

产品介绍

Haloperidol decanoate AI Summary

Haloperidol decanoate shows high affinity for dopamine receptors, particularly D2long (Ki = 1.8 nM) and D2short (Ki = 0.46 nM) receptors, moderate affinity for the D3 receptor (Ki = 3.5 nM), and lower affinity for the D4.4 receptor (Ki = 5.8 nM). It exhibits much weaker activity for the D1 receptor (Ki = 140.0 nM), suggesting potential use in dopamine-related bioactivity. However, Haloperidol decanoate also induces drug-induced liver injury in humans, with a severity class index score of 3.0. Additionally, it exhibits antiviral activity against SARS-CoV-2, showing inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM concentration after 48 hours (3.24% inhibition) and in VERO-6 cells (0.15% inhibition at 10 µM after 48 hours, with IC50 values >20000.0 nM and >19952.62 nM). It also inhibits the SARS-CoV-2 3CL-Pro protease by 9.491% at 20 µM. Furthermore, Haloperidol decanoate demonstrates inhibitory activity on the human HDAC6 enzyme, with an inhibition rate of -7.69% using a commercial peptide substrate and -3.25% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Haloperidol decanoate (KD 16) is a typical antipsychotic agent utilized as maintenance treatment for schizophrenia and mood disorders formulated as an ester for intramuscular injection.
别名	Neoperidole, KD-136, KD 16, KD 136, Haldol

化学信息

分子量	530.11
分子式	C₃₁H₄₁ClFNO₃
CAS No.	74050-97-8
Smiles	O(C(CCCCCCCCC)=O)C1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3
密度	1.1074 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (113.18 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.72 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8864 mL	9.4320 mL	18.8640 mL	94.3200 mL
5 mM	0.3773 mL	1.8864 mL	3.7728 mL	18.8640 mL
10 mM	0.1886 mL	0.9432 mL	1.8864 mL	9.4320 mL
20 mM	0.0943 mL	0.4716 mL	0.9432 mL	4.7160 mL
50 mM	0.0377 mL	0.1886 mL	0.3773 mL	1.8864 mL
100 mM	0.0189 mL	0.0943 mL	0.1886 mL	0.9432 mL