嗜乳脂蛋白 (Butyrophilins)

Expression system: HEK293 Cells
Length: 1-248, Extracellular Domain
Activity: Not Tested

BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.

Expression system: HEK293 Cells
Length: 1-248, Extracellular Domain
Activity: Not Tested

BTN3A1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.16 kDa and the accession number is NP_919423.1.

Butyrophilin-like 6 (BTNL6) is a member of the BTN MOG Ig-superfamily and functions with BTNL1 as a regulator of immune cell proliferation. The Btnl6 gene is found only in mice. BTNL6 expression is coordinated as a heteromeric protein with BTNL1, and the presence of this complex is correlated with expansion of gamma δ T cells, especially those containing V gamma 7Vδ4 TCR. Btnl6 shows striking sequence similarity to Skint1; is also largely restricted to an epithelial tissue (the small intestine) replete with T cells. Our in-house studies showed BTNL6 co-inhibited anti-CD3 induced IL-2 secretion on CD3+ cells.

Expression system: E. coli
Length: 28-245, Partial of Isoform 4
Activity: Not Tested

Expression system: HEK293 Cells
Length: 30-254, Extracellular Domain
Activity: Not Tested

Expression system: E. coli
Length: 30-254, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 33-237, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 33-237, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 36-257, Extracellular Domain
Activity: Not Tested

Butyrophilin-like 4, also known as BTLN4, BTN3A3 (human) and BTN3A2 (rat) is an approximately 65 kDa member of the butyrophilin family that may play a role in immune regulation. BTNL4 shows striking sequence similarity to Skint1, is also largely restricted to an epithelial tissue (the small intestine) replete with T cells, plays a role in T-cell responses in the adaptive immune response.

Butyrophilin-like 2 (BTNL2) is a member of the BTN MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Mouse BTNL2 is type I transmembrane glycoprotein that contains an extracellular domain (ECD), a transmembrane region and a short cytoplasmic domain. The ECD features two V-type Ig-like domains, two C-type Ig-like domains, and four glycosylation sites. BTNL2 is expressed in epithelial cells of the small intestine, colonic dendritic cells, and in cells of the lymph node. BTNL2 expression is upregulated in T cells following activation, a characteristic BTNL2 shares with the homologous B7 family of costimulatory molecules. BTNL2 negatively regulates T cells by inhibiting proliferation and inflammatory cytokine secretion. It also increases the expression of FoxP3 in T cells to promote regulatory T cell development. Single nucleotide polymorphisms in BTNL2 are associated with a risk for sporadic prostate cancer, rheumatoid arthritis, sarcoidosis, ulcerative colitis, and other inflammatory diseases.

Expression system: HEK293 Cells
Length: 24-455, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 35-256, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 48-160, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-242, Partial
Activity: Not Tested

Butyrophilin (BTN) genes encode a set of related proteins. Cell surface BTN2A2 protein, such as the B7 family molecule programmed death ligand 1, was upregulated upon activation of T cells.BTN2A2 is a co-inhibitory molecule that modulates T cell-mediated immunity.

BTN3A1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.

Expression system: HEK293 Cells
Length: 29-248, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-247, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-242, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 30-254, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 30-254, Extracellular Domain
Activity: ELISA