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Anti-Cortisol Binding Globulin Antibody (8I857)
还可以产品编号 TMAY-03228
Anti-Cortisol Binding Globulin Antibody (8I857) 是一种 Rabbit 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (8I857) 可用于 ELISA。
Anti-Cortisol Binding Globulin Antibody (8I857)
Anti-Cortisol Binding Globulin Antibody (8I857)
还可以产品编号 TMAY-03228
Anti-Cortisol Binding Globulin Antibody (8I857) 是一种 Rabbit 抗体，靶向 Cortisol Binding Globulin。Anti-Cortisol Binding Globulin Antibody (8I857) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Cortisol Binding Globulin Antibody (8I857) is a Rabbit antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (8I857) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8I857 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SerpinA6 (rM SerpinA6; TMPY-02107; Q06770; Met1-Ala397). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse SerpinA6 protein (TMPY-02107) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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