Hydrocortisone acetate

Name: Hydrocortisone acetate
Brand: TargetMol
SKU: T1243
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.22%

货号 T1243Cas号 50-03-3

别名 醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetate

Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。

Hydrocortisone acetate

一键复制产品信息

很棒

纯度: 99.22%

货号 T1243 别名 醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetateCas号 50-03-3

Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。

规格	价格	库存
200 mg	¥ 133	现货
500 mg	¥ 196	待询
1 g	¥ 328	待询
1 mL x 10 mM (in DMSO)	¥ 150	现货

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纯度: 99.22%

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COA HNMR LCMS 产品操作手册

产品介绍

Hydrocortisone acetate AI Summary

Hydrocortisone acetate exhibits a variety of bioactivities and pharmacological properties across different assays and receptor interactions. It shows strong binding affinity to corticosteroid-binding globulin (CBG) with a log K of 7.553 and a Ki value of 28.18 nM. For glucocorticoid receptors, it has a high relative binding affinity (RBA) in liver (RBA = 10.0 at 4 hr) and moderate affinity in hepatoma tissue cells (RBA = 9.0 at 4 hr, and RBA = 8.0 at 24 hr), but lower affinity in the thymus (RBA = 3.4 at 4 hr, and RBA = 3.3 at 24 hr). The compound also demonstrates negligible binding to progestin, androgen, and mineralocorticoid receptors. Additionally, it induces Tyrosine Aminotransferase activity to 91% relative to Dexamethasone. Hydrocortisone acetate shows similar potency to fluocinolone 16,17-acetonide in human vasoconstrictor tests and comparable anti-inflammatory effects to hydrocortisone in rat granuloma assays. From a physicochemical perspective, Hydrocortisone acetate has a logP value of 2.26 (HPLC method) and 2.19 (general method), indicating moderate lipophilicity. It has a high HPLC capacity factor (log k'w = 1.93), suggesting good retention on the HPLC column, and an intrinsic aqueous solubility of logS0 = -4.34 at pH 10. In antiviral assays, Hydrocortisone acetate inhibits SARS-CoV-2-induced cytotoxicity in VERO-6 cells and shows inhibitory activity against SARS-CoV-2 3CL-Pro protease (13.7% inhibition at 20 µM). It also demonstrates moderate to high inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells (93.94% and 91.1% inhibition, respectively, at 10 µM). In various bioactivity assays, Hydrocortisone acetate acts as an inhibitor of pathways such as AmpC Beta-Lactamase, Nrf2 signaling, Histone Lysine Methyltransferase G9a, ERG Ets/DNA interaction, and several others. Additionally, it exhibits antifungal and antibacterial activity against multiple strains, including Candida albicans, Cryptococcus neoformans, Escherichia coli, and Staphylococcus aureus MRSA, among others. Overall, Hydrocortisone acetate has potential therapeutic applications across various biological pathways and disease models due to its broad spectrum of bioactivities and moderate lipophilicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
别名	醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetate

化学信息

分子量	404.5
分子式	C₂₃H₃₂O₆
CAS No.	50-03-3
Smiles	C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COC(C)=O)=O)O)[H]
密度	1.26 g/cm/3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (148.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.18 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	123.6094 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
20 mM	0.1236 mL	0.6180 mL	1.2361 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2361 mL