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Anti-Angiotensinogen Antibody (4R806)

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Anti-Angiotensinogen Antibody (4R806)
产品编号 TMAY-01435
别名 angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Anti-Angiotensinogen Antibody (4R806) 是一种 Rabbit 抗体，靶向 Angiotensinogen。Anti-Angiotensinogen Antibody (4R806) 可用于 IHC-P。

Anti-Angiotensinogen Antibody (4R806)
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Anti-Angiotensinogen Antibody (4R806)

Rating icon 还可以
Anti-Angiotensinogen Antibody (4R806)
产品编号 TMAY-01435 别名 angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Anti-Angiotensinogen Antibody (4R806) 是一种 Rabbit 抗体，靶向 Angiotensinogen。Anti-Angiotensinogen Antibody (4R806) 可用于 IHC-P。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-Angiotensinogen Antibody (4R806) is a Rabbit antibody targeting Angiotensinogen. Anti-Angiotensinogen Antibody (4R806) can be used in IHC-P.
别名angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Ig Type
Rabbit IgG
克隆号
4R806
交叉反应
Human
验证活性
1. Immunochemical staining of human AGT in human cirrhosis with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
2. Immunochemical staining of human AGT in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nerve cell.
应用
IHC-P
推荐剂量
IHC-P: 1:100-1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA8 / Angiotensinogen / AGT (rh SerpinA8 / Angiotensinogen / AGT; TMPY-01232; NP_000020.1; Met1-Ala485).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human SerpinA8 / Angiotensinogen / AGT protein (TMPY-01232)
抗原种属
Human
研究领域
Serine Proteases and Regulators
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

serpin peptidase inhibitor, clade A, member 8angiotensinogen

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