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Retro-2 cycl

Name: Retro-2 cycl
Brand: TargetMol
SKU: T12711
Price: 233 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.89%

货号 T12711Cas号 1429192-00-6

别名 RN 1-001

Retro-2 cycl 是一种抗病毒剂，是一种逆行运输抑制剂，抑制 JCPyV（IC50s：54 μM）和 HPV16 假病毒（IC50s：160 μM）。

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Retro-2 cycl

一键复制产品信息

很棒

纯度: 99.89%

货号 T12711 别名 RN 1-001Cas号 1429192-00-6

Retro-2 cycl 是一种抗病毒剂，是一种逆行运输抑制剂，抑制 JCPyV（IC50s：54 μM）和 HPV16 假病毒（IC50s：160 μM）。

规格	价格	库存
1 mg	¥ 233	现货
5 mg	¥ 538	现货
10 mg	¥ 863	现货
25 mg	¥ 1,730	现货
50 mg	¥ 2,790	现货
100 mg	¥ 4,530	现货
200 mg	¥ 6,380	现货
500 mg	¥ 9,460	现货
1 mL x 10 mM (in DMSO)	¥ 593	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Retro-2 cycl AI Summary

Retro-2 cycl exhibits multifaceted bioactivity. It shows significant cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells, with a 100% activity level and an EC50 value of 27300.0 nM. Additionally, it inhibits shiga toxin retrograde transport in these cells with a 36.9% inhibition rate. The compound also demonstrates antiviral properties, reducing viral infectivity by 57.5% against JC polyomavirus after pre-incubation with a concentration of 25 µM for 0.5 hours. Its IC50 values are 54000.0 nM for JC polyomavirus and 160000.0 nM for HPV16 pseudovirus. Furthermore, Retro-2 cycl inhibits Escherichia coli Stx1 interaction in HeLa cells, effectively reducing the stimulation of protein synthesis as indicated by radiolabelled-methionine incorporation with an EC50 of 27300.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Retro-2 cycl is an antiviral agent and a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface. Retro-2 cycl inhibits JCPyV(IC50s: 54 μM) and HPV16 pseudovirus(IC50s: 160 μM).
靶点活性	HPV-16:160 μM, JCPyV:54 μM
别名	RN 1-001

化学信息

分子量	320.41
分子式	C₁₉H₁₆N₂OS
CAS No.	1429192-00-6
Smiles	Cc1ccc(s1)C1Nc2ccccc2C(=O)N1c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 0.1 mg/mL (insoluble)

DMSO: 45 mg/mL (140.45 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.24 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1210 mL	15.6050 mL	31.2100 mL	156.0501 mL
5 mM	0.6242 mL	3.1210 mL	6.2420 mL	31.2100 mL
10 mM	0.3121 mL	1.5605 mL	3.1210 mL	15.6050 mL
20 mM	0.1561 mL	0.7803 mL	1.5605 mL	7.8025 mL
50 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1210 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5605 mL