Name: ZSET1446
Brand: TargetMol
SKU: T8448
Price: 433 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 433

In Stock

5 mg

¥ 987

In Stock

10 mg

¥ 1,550

In Stock

25 mg

¥ 2,610

In Stock

50 mg

¥ 3,710

In Stock

100 mg

¥ 5,110

In Stock

200 mg

¥ 6,890

In Stock

1 mL x 10 mM (in DMSO)

¥ 1,270

In Stock

产品介绍

生物活性

产品描述	ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
体内活性	ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1].
动物实验	ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1].
别名	ZSET-1446, ST-101

化学信息

分子量	236.27
分子式	C₁₅H₁₂N₂O
CAS No.	887603-94-3
Smiles	O=C1N=C2C=CC=CN2C11Cc2ccccc2C1
密度	1.32 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 29 mg/mL (122.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2324 mL	21.1622 mL	42.3245 mL	211.6223 mL
5 mM	0.8465 mL	4.2324 mL	8.4649 mL	42.3245 mL
10 mM	0.4232 mL	2.1162 mL	4.2324 mL	21.1622 mL
20 mM	0.2116 mL	1.0581 mL	2.1162 mL	10.5811 mL
50 mM	0.0846 mL	0.4232 mL	0.8465 mL	4.2324 mL
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1162 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

ZSET1446

ZSET1446

产品介绍

计算器

体内实验配液计算器

剂量转换

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