Name: Otamixaban
Brand: TargetMol
SKU: T16410
Price: 1899 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

2 mg

¥ 1,899

现货

产品介绍

生物活性

产品描述	Otamixaban (FXV673) is a selective and highly effective Xa inhibitor that inhibits the generation of thrombin and can be used to study acute coronary syndrome.
靶点活性	TMPRSS2:18.7 × 10 μM
体外活性	HTS 分析表明 Otamixaban 对 TMPRSS2 的抑制作用。 IC50 = 18.7 × 103 nM。[5] Calu-3 细胞系中的 Otamixaban 抑制 SARS-COV-2 S 介导的病毒进入。[5]
体内活性	Otamixaban is highly efficacious in rodent, canine and porcine models of thrombosis showed in vivo experiments. Recent clinical findings indicate that Otamixaban is efficacious, safe, and well-tolerated in humans and therefore has considerable potential for the treatment of acute coronary syndrome.
别名	奥米沙班, XRP 0673, RPR 130673, FXV-673, FXV673, FXV 673

化学信息

分子量	446.5
分子式	C₂₅H₂₆N₄O₄
CAS No.	193153-04-7
Smiles	C(N[C@@H]([C@@H](CC1=CC(C(=N)N)=CC=C1)C(OC)=O)C)(=O)C2=CC=C(C=C2)C=3C=CN(=O)=CC3
密度	1.25 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 40 mg/mL (89.59 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

体内实验配液计算器