Name: ZG-2305
Brand: TargetMol
SKU: T200939
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	ZG-2305 is a selective, orally active inhibitor of FIH with Ki values of 79.6 nM and 2786 nM for FIH and PHD2, respectively. It increases EGLN3 gene expression, reduces cellular triglyceride levels, and decreases lipid accumulation, making it suitable for obesity and fatty liver disease research.
靶点活性	PHD2:2786 nM (Ki), FIH (factor inhibiting HIF):79.6 nM (Ki)
体内活性	ZG-2305在雄性小鼠中能够逆转由高脂肥胖引起的体重增加和肝脂肪变性异常，在HF-CDAA饮食诱导的NASH模型中改善非酒精性脂肪性肝炎相关的肝损伤、脂肪变质、炎症以及纤维化问题[1]。
别名	ZG2305, ZG 2305

化学信息

分子量	408.19
分子式	C₁₇H₁₁Cl₂N₃O₅
CAS No.	2962103-54-2
Smiles	O=C(O)CNC(=O)C=1N=CC(=CC1O)C=2ON=C(C2)C=3C=C(Cl)C=C(Cl)C3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

ZG-2305