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Nω-Hydroxy-nor-L-Arginine Dihydrochloride

Name: Nω-Hydroxy-nor-L-Arginine Dihydrochloride
Brand: TargetMol
SKU: T9096
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T9096Cas号 291758-32-2

别名 NΩ-羟基或- L -精氨酸盐酸盐

Nω-Hydroxy-nor-L-Arginine Dihydrochloride 是一种竞争性和可逆的精氨酸酶抑制剂。

Nω-Hydroxy-nor-L-Arginine Dihydrochloride

一键复制产品信息

很棒

纯度: 99.84%

货号 T9096 别名 NΩ-羟基或- L -精氨酸盐酸盐Cas号 291758-32-2

Nω-Hydroxy-nor-L-Arginine Dihydrochloride 是一种竞争性和可逆的精氨酸酶抑制剂。

规格	价格	库存
1 mg	¥ 315	现货
5 mg	¥ 768	现货
10 mg	¥ 1,180	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,470	现货
100 mg	¥ 4,690	现货
500 mg	¥ 9,360	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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实验操作小课堂

常见问题解答

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纯度: 99.84%

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资源下载:

COA LCMS HNMR IC 产品操作手册

产品介绍

Nω-Hydroxy-nor-L-Arginine Dihydrochloride AI Summary

Nω-Hydroxy-nor-L-Arginine Dihydrochloride exhibits significant inhibitory bioactivity against various arginase enzymes. It demonstrates potent inhibition of mouse macrophage arginase with an IC50 value of 50,000 nM and rat liver arginase with an IC50 value of 2,000 nM. It also inhibits bovine liver arginase, reducing urea production from L-arginine, with an IC50 value of 1,700 nM assessed through spectrophotometric analysis. For human recombinant ARG1, it shows an IC50 of 450 nM and binds with high affinity, having a Kd value of 47 nM. Additionally, Nω-Hydroxy-nor-L-Arginine Dihydrochloride inhibits human ARG2 with a Ki value of 51 nM. In rat models, the compound exhibits a half-life of 0.25 hours and 100% oral bioavailability. It effectively inhibits human ARG1 with IC50 values ranging from 1,360 nM to 2000 nM and exhibits binding affinities varying in different pH conditions. These characteristics suggest its potential as a therapeutic enzyme inhibitor targeting various forms of arginase..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a competitive and reversible inhibitor of arginase
别名	NΩ-羟基或- L -精氨酸盐酸盐

化学信息

分子量	249.10
分子式	C₅H₁₄Cl₂N₄O₃
CAS No.	291758-32-2
Smiles	Cl.Cl.N[C@@H](CCNC(=N)NO)C(O)=O
密度	no data available

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 1.76 mg/mL (7.07 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0145 mL	20.0723 mL	40.1445 mL	200.7226 mL
5 mM	0.8029 mL	4.0145 mL	8.0289 mL	40.1445 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Nω-Hydroxy-nor-L-Arginine Dihydrochloride NωHydroxynorLArginine Dihydrochloride Nω-Hydroxy-nor-L-Arginine Nω Hydroxy nor L Arginine Dihydrochloride Nw-Hydroxy-nor-L-Arginine Dihydrochloride Nw-Hydroxy-nor-L-Arginine Nomega-Hydroxy-nor-L-Arginine Dihydrochloride Nomega-Hydroxy-nor-L-Arginine arginase

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Nω-Hydroxy-nor-L-Arginine Dihydrochloride

Nω-Hydroxy-nor-L-Arginine Dihydrochloride