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Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)

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货号 TMPH-03529

别名 chp, CHIPS, Chemotaxis inhibitory protein

Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is Q6GFB3.

Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)
其他形式的 “Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)”:
Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)TMPH-03528
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Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)

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货号 TMPH-03529 别名 chp, CHIPS, Chemotaxis inhibitory protein

Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is Q6GFB3.

规格价格库存数量
5 μg
¥ 922
20日内发货
10 μg
¥ 1,530
20日内发货
20 μg
¥ 2,570
20日内发货
50 μg
¥ 3,880
20日内发货
100 μg
¥ 5,370
20日内发货
200 μg
¥ 7,660
20日内发货
500 μg
¥ 12,300
20日内发货
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产品介绍

生物活性
产品描述
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is Q6GFB3.
靶点活性
RBL-C5aR cells:69 nM, binding of C5a to C5aR:6.7 nM, activation of C5aR by C5a:2.44 μM
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium.
种属
Staphylococcus aureus
表达系统
P. pastoris (Yeast)
标签N-6xHis
蛋白编号Q6GFB3
氨基酸序列FTFEPFPTNEEIESNKKMLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY
蛋白构建29-149 aa
蛋白纯度
> 90% as determined by SDS-PAGE.
Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)
缓冲液Tris-based buffer, 50% glycerol
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名chp, CHIPS, Chemotaxis inhibitory protein
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量16.1 kDa (Predicted), 17 kDa (Reducing conditions)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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技术支持

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