Takeda-6d

Name: Takeda-6d
Brand: TargetMol
SKU: T22436
Price: 858 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.27%

货号 T22436Cas号 1125632-93-0

Takeda-6d 是一种新型、有效的 DFG-out RAF/血管内皮生长因子受体 2 (VEGFR2) 抑制剂，IC50 分别为 7.0 nM 和 2.2 nM。

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Takeda-6d

一键复制产品信息

很棒

纯度: 98.27%

货号 T22436Cas号 1125632-93-0

Takeda-6d 是一种新型、有效的 DFG-out RAF/血管内皮生长因子受体 2 (VEGFR2) 抑制剂，IC50 分别为 7.0 nM 和 2.2 nM。

规格	价格	库存
1 mg	¥ 858	现货
2 mg	¥ 1,190	现货
5 mg	¥ 1,750	现货
10 mg	¥ 2,590	现货
25 mg	¥ 4,150	现货
50 mg	¥ 5,610	现货
100 mg	¥ 7,560	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 2,250	现货

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产品介绍

Takeda-6d AI Summary

Takeda-6d is a potent bioactive compound involved in drug metabolism and exhibiting significant enzymatic inhibition. In human liver microsomes, it undergoes 2-amino derivative formation at a concentration of 30 μM after 60 minutes, with drug metabolism accounting for 2.4%. It demonstrates substantial metabolic stability, retaining 109.5% of the compound under the same conditions. The compound shows a thermodynamic solubility of 3.6 μg/mL in JP2 solution at pH 6.8 in the presence of 20 mmol/L bile acid. Additionally, Takeda-6d acts as a potent inhibitor of the BRAF V600E mutant and VEGFR2 kinase with IC50 values of 5.6 nM and 2.8 nM, respectively, highlighting its potential as a targeted therapy candidate. It also exhibits inhibitory activity against Plasmodium falciparum (DD2) proliferation with a potency of 3346.9 nM as evidenced by qHTS profiling assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.
靶点活性	VEGFR2:2.2 nM, Raf:7.0 nM

化学信息

分子量	547.99
分子式	C₂₇H₁₉ClFN₅O₃S
CAS No.	1125632-93-0
Smiles	Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)cc1NC(=O)c1cccc(c1Cl)C1(CC1)C#N
密度	no data available
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (118.62 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8249 mL	9.1243 mL	18.2485 mL	91.2425 mL
5 mM	0.3650 mL	1.8249 mL	3.6497 mL	18.2485 mL
10 mM	0.1825 mL	0.9124 mL	1.8249 mL	9.1243 mL
20 mM	0.0912 mL	0.4562 mL	0.9124 mL	4.5621 mL
50 mM	0.0365 mL	0.1825 mL	0.3650 mL	1.8249 mL
100 mM	0.0182 mL	0.0912 mL	0.1825 mL	0.9124 mL