Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1]. |
体外活性 | Keap1-Nrf2-IN-4 (compound 4g) (72 h) shows anti-proliferation activity (IC 50 s of 2.55, 3.88, 3.74, 2.89 μM in MGC-803, MCF-7, A549, HepG-2 cells, respectively) [1]. Keap1-Nrf2-IN-4 inhibits neddylation of cullin1, cullin3, cullin5 [1]. Keap1-Nrf2-IN-4 blocks the migration ability of MGC-803 without cell cycle arrest [1]. Keap1-Nrf2-IN-4 (24, 48 h) induces apoptosis of MGC-803 and HGC-27 cells in concentration- and time-dependent manners [1]. Cell Proliferation Assay [1] Cell Line: MGC-803, MCF-7, A549, HepG-2 cells Concentration: Incubation Time: 72 h Result: Showed anti-proliferation activity (IC 50 of 2.55, 3.88, 3.74, 2.89 μM in MGC-803, MCF-7, A549, HepG-2 cells, respectively). Apoptosis Analysis [1] Cell Line: MGC-803, HGC-27 cells Concentration: 2.5, 5, 7.5 μM for MGC-803 cells; 3, 6, 9 μM for HGC-27 cells Incubation Time: 24 h, 48 h Result: Induced apoptosis of MGC-803 and HGC-27 cells in concentration- and time-dependent manners. |
体内活性 | Keap1-Nrf2-IN-4 (50, 100 mg/kg; i.g.; per day for 21 days) exhibits antitumor activity on xenograft model without obvious side effect [1]. Animal Model: 5-6 weeks, 18-20 g, NOD SCID mice (xenograft tumor model) [1] Dosage: 50, 100 mg/kg Administration: i.g.; per day, 21 days Result: Exihibited good antitumor activity on xenograft model without obvious side effect. |
分子量 | 390.56 |
分子式 | C26H34N2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Keap1-Nrf2-IN-4 Inhibitor inhibitor inhibit