kb NB 142-70

Name: kb NB 142-70
Brand: TargetMol
SKU: T2062
Price: 333 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.64%

货号 T2062Cas号 1233533-04-4

kb NB 142-70 是一种PKD 有效抑制剂，具有抗肿瘤活性，对 PKD1、PKD2 和 PKD3 的IC50值分别为 28.3 nM、58.7 nM 和 53.2 nM。

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kb NB 142-70

一键复制产品信息

很棒

纯度: 99.64%

货号 T2062Cas号 1233533-04-4

kb NB 142-70 是一种PKD 有效抑制剂，具有抗肿瘤活性，对 PKD1、PKD2 和 PKD3 的IC50值分别为 28.3 nM、58.7 nM 和 53.2 nM。

规格	价格	库存
1 mg	¥ 333	现货
2 mg	¥ 478	现货
5 mg	¥ 753	现货
10 mg	¥ 995	现货
25 mg	¥ 2,320	现货
50 mg	¥ 3,590	现货
100 mg	¥ 5,130	现货
1 mL x 10 mM (in DMSO)	¥ 872	现货

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产品介绍

kb NB 142-70 AI Summary

kb NB 142-70 exhibits bioactivities including potent inhibition of human recombinant PKD1 with an IC50 value of 28.3 nM in a radiometric assay and inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells with an IC50 of 2200.0 nM as determined by Western blotting. It also demonstrates antiviral properties against SARS-CoV-2, inhibiting the virus-induced cytotoxicity of VERO-6 cells with a 1.45% inhibition rate at a concentration of 10 µM, and showing 21.18% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM through a FRET-based assay. The compound exhibits varying bioactivities in different cell lines, inhibiting growth in HEK293T cells (growth rates: -0.06 to -0.51) and human fibroblasts (growth rates: -0.69 to -1.0), and showing mixed effects in U2OS cells (growth rates: -0.99 to 0.56) based on Incucyte cell viability assays. Additionally, kb NB 142-70 demonstrates cytotoxic activity against human HepG2 cells with an IC50 value of 1000.0 nM in the CellTiter-Glo luminescent cell viability assay, indicating its potential for cell-type-specific effects on cell viability and growth..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).
靶点活性	PKD1:28.3nM, PKD2:58.7nM, PKD3:53.2 nM

化学信息

分子量	251.32
分子式	C₁₁H₉NO₂S₂
CAS No.	1233533-04-4
Smiles	Oc1ccc2sc3c(SCCNC3=O)c2c1
密度	1.495 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25.13 mg/mL (99.99 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9790 mL	19.8950 mL	39.7899 mL	198.9495 mL
5 mM	0.7958 mL	3.9790 mL	7.9580 mL	39.7899 mL
10 mM	0.3979 mL	1.9895 mL	3.9790 mL	19.8950 mL
20 mM	0.1989 mL	0.9947 mL	1.9895 mL	9.9475 mL
50 mM	0.0796 mL	0.3979 mL	0.7958 mL	3.9790 mL