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3'-Methoxyflavonol

Name: 3'-Methoxyflavonol
Brand: TargetMol
SKU: T8035
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.32%

货号 T8035Cas号 76666-32-5

别名 3-羟基-3'-甲氧基黄酮

3'-Methoxyflavonol 是一种神经介肽 U 2 受体的选择性激动剂。

为众多的药物研发团队赋能，

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3'-Methoxyflavonol

一键复制产品信息

很棒

纯度: 99.32%

货号 T8035 别名 3-羟基-3'-甲氧基黄酮Cas号 76666-32-5

3'-Methoxyflavonol 是一种神经介肽 U 2 受体的选择性激动剂。

规格	价格	库存
5 mg	¥ 145	现货
10 mg	¥ 192	现货
25 mg	¥ 293	现货
50 mg	¥ 415	现货
100 mg	¥ 597	现货
200 mg	¥ 869	待询
1 mL x 10 mM (in DMSO)	¥ 373	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.32%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

3'-Methoxyflavonol AI Summary

3'-Methoxyflavonol exhibits a diverse range of bioactivities. It has shown vasorelaxant activity in Sprague-Dawley rat thoracic aorta under both endothelium-dependent and endothelium-independent conditions, with various EC50 values indicating its potency. Additionally, it demonstrates antioxidant properties by reducing superoxide levels and DPPH scavenging activities within the same experimental model. 3'-Methoxyflavonol is also potent as an inhibitor in various biochemical assays, targeting interactions such as Menin-MLL, human Jumonji Domain-containing 2E (JMJD2E), and Thyroid Stimulating Hormone Receptor, among others. It inhibits multiple enzymes including Tyrosyl-DNA Phosphodiesterase (TDP1), Cytochrome P450 isoforms (2C19, 2D6, 2C9, 3A4), 12-human lipoxygenase (12-hLO), and 15-Hydroxyprostaglandin Dehydrogenase (HPGD), and modulates cellular functions like ERK signaling pathway and Tau fibril formation. Furthermore, it shows antiviral properties against Lassa Virus and Marburg Virus, and anti-parasitic activity against Trypanosoma brucei brucei Lister 427, with an EC50 of 2320.0 nM and a selectivity index of 4.0. In prostate cancer models, it inhibits prostate-specific antigen (PSA) and androgen receptor (AR) expression in human 22Rv1 cells, showing antiproliferative activity with an IC50 of 5300.0 nM. Moreover, it exhibits cytotoxic activity against human HCT116 cells, with notable viability reduction at 15 uM after 48 hours. Overall, 3'-Methoxyflavonol demonstrates significant potential due to its broad bioactivity spectrum including vascular, antioxidant, enzymatic inhibition, antiviral, antiproliferative, and antitrypanosomal properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R).
别名	3-羟基-3'-甲氧基黄酮

化学信息

分子量	268.26
分子式	C₁₆H₁₂O₄
CAS No.	76666-32-5
Smiles	COc1cccc(c1)-c1oc2ccccc2c(=O)c1O
密度	1.353g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 155 mg/mL (577.8 mM), Heating is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.3 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7277 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8639 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。