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DY131

Name: DY131
Brand: TargetMol
SKU: T2250
Price: 217 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.66%

货号 T2250Cas号 95167-41-2

别名 GSK 9089, DY-131, DY 131

DY131 (DY-131) 是选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。它对Smo 的信号传导具有抑制作用。

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DY131

一键复制产品信息

很棒

纯度: 99.66%

货号 T2250 别名 GSK 9089, DY-131, DY 131Cas号 95167-41-2

DY131 (DY-131) 是选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。它对Smo 的信号传导具有抑制作用。

规格	价格	库存
1 mg	¥ 217	现货
5 mg	¥ 478	现货
10 mg	¥ 828	现货
25 mg	¥ 1,580	现货
50 mg	¥ 2,890	现货
100 mg	¥ 4,180	现货
200 mg	¥ 5,750	现货
1 mL x 10 mM (in DMSO)	¥ 538	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.66%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

DY131 AI Summary

DY131 exhibits a multifaceted bioactivity profile encompassing various targets and assay systems. Notably, it shows specific activity related to Estrogen-Related Receptor gamma, with an EC50 of 130.0 nM in a FRET assay, 55.0% efficacy, and an IC50 of 660.0 nM for inhibiting [3H]4-OHT binding. It also demonstrates inhibitory effects on various enzymes and receptors, including HSD17B4, JMJD2E, HADH2, Aldehyde Dehydrogenase 1, 15-hLO, HPGD, Caspase-1, and Cytochrome P450 3A4, along with bioactivity in assays targeting ROR gamma transcriptional activity, Tau Fibril Formation, cancer cells with p53 mutations, and several viral infections like Lassa Virus, Marburg Virus, and Foot and Mouth Disease Virus. Additionally, it shows antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, with inhibition rates varying from -0.94% to 0.07%. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease at 20 µM, with varying inhibition percentages of -2.72% and -16.73%. DY131 also exhibits substantial inhibitory activity against human HDAC6, with inhibition percentages ranging from 49.5% to 94.25%, and an IC50 of 2030.0 nM in a specific enzymatic assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
别名	GSK 9089, DY-131, DY 131

化学信息

分子量	311.38
分子式	C₁₈H₂₁N₃O₂
CAS No.	95167-41-2
Smiles	CCN(CC)c1ccc(C=NNC(=O)c2ccc(O)cc2)cc1
密度	1.11 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 31.1 mg/mL (99.88 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2115 mL	16.0576 mL	32.1151 mL	160.5755 mL
5 mM	0.6423 mL	3.2115 mL	6.4230 mL	32.1151 mL
10 mM	0.3212 mL	1.6058 mL	3.2115 mL	16.0576 mL
20 mM	0.1606 mL	0.8029 mL	1.6058 mL	8.0288 mL
50 mM	0.0642 mL	0.3212 mL	0.6423 mL	3.2115 mL