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Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871)
还可以产品编号 TMAY-00577
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) 是一种 Mouse 抗体，靶向 Alpha 2 Antiplasmin/SerpinF2。Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) 可用于 FCM。
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871)
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871)
还可以产品编号 TMAY-00577
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) 是一种 Mouse 抗体，靶向 Alpha 2 Antiplasmin/SerpinF2。Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) 可用于 FCM。
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| 产品描述 | Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) is a Mouse antibody targeting Alpha 2 Antiplasmin/SerpinF2. Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (3S871) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3S871 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human SERPINF2 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human SERPINF2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinF2 (rh SerpinF2; TMPY-01398; NP_000925.2; Met1-Lys491). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta at a moderate level. It is indicated that Serpin F2 is a key regulator of plasmin-mediated proteolysis in these tissues. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. SerpinF2 is one of the inhibitors of fibrinolysis, which acts as the primary inhibitor of plasmin(ogen). It is a specific plasmin inhibitor, and is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the congenital deficiency of Alpha-2 antiplasmin causes a rare bleeding disorder because of increased fibrinolysis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SerpinF2 Protein (TMPY-01398) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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