Polaprezinc is an bioavailable chelate comprised of zinc and L-carnosine, known for its gastrointestinal protective properties, as well as its anti-ulcer, antioxidant, and anti-inflammatory effects.

Male C57BL/6J mice (8-weeks-old; weight, ~20 g). The mice are acclimated for 7 days. They are housed 4-5/cage and fed a laboratory rodent pellet formula and tap water ad libitum. Mice are maintained at a constant temperature of 22°C±0.5°C, a humidity of 50%±5% and are exposed to 12 h light/dark cycles. The mice orally receive 100 mg/kg body weight Polaprezinc in the drinking water. The mice are irradiated at a dose rate of ~200 cGy/min using a 150 kVp X-ray unit. For dosimetry, a probe connected to an electrometer system is placed close to the target site.