Name: Taurolidine
Brand: TargetMol
SKU: T7533
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

25 mg

¥ 117

In Stock

50 mg

¥ 163

In Stock

100 mg

¥ 247

In Stock

200 mg

¥ 363

In Stock

产品介绍

生物活性

产品描述	Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
体外活性	Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
体内活性	In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
细胞实验	In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
动物实验	In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].
别名	牛磺罗定

化学信息

分子量	284.36
分子式	C₇H₁₆N₄O₄S₂
CAS No.	19388-87-5
Smiles	O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1
密度	1.466 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (175.83 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5167 mL	17.5833 mL	35.1667 mL	175.8335 mL
5 mM	0.7033 mL	3.5167 mL	7.0333 mL	35.1667 mL
10 mM	0.3517 mL	1.7583 mL	3.5167 mL	17.5833 mL
20 mM	0.1758 mL	0.8792 mL	1.7583 mL	8.7917 mL
50 mM	0.0703 mL	0.3517 mL	0.7033 mL	3.5167 mL
100 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7583 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

Taurolidine

Taurolidine

产品介绍

计算器

体内实验配液计算器

剂量转换

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