规格

价格

库存

数量

25 mg

¥ 117

现货

50 mg

¥ 163

现货

100 mg

¥ 247

现货

200 mg

¥ 363

现货

生物活性

产品描述	Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
体外活性	Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
体内活性	In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
细胞实验	In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
动物实验	In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].
别名	牛磺罗定

化学信息

分子量	284.36
分子式	C₇H₁₆N₄O₄S₂
CAS No.	19388-87-5
Smiles	O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1
密度	1.466 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (175.83 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5167 mL	17.5833 mL	35.1667 mL	175.8335 mL
5 mM	0.7033 mL	3.5167 mL	7.0333 mL	35.1667 mL
10 mM	0.3517 mL	1.7583 mL	3.5167 mL	17.5833 mL
20 mM	0.1758 mL	0.8792 mL	1.7583 mL	8.7917 mL
50 mM	0.0703 mL	0.3517 mL	0.7033 mL	3.5167 mL
100 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7583 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Taurolidine

Taurolidine

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Taurolidine

Taurolidine

Taurolidine 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词