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Zotepine

Name: Zotepine
Brand: TargetMol
SKU: T19680
Price: 388 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.78%

货号 T19680Cas号 26615-21-4

别名 佐替平

Zotepine 是一种抗精神病剂，是有效的5-HT2A、5-HT2C、组胺H1、α1-肾上腺素能和多巴胺D2受体拮抗剂，Kd 值分别为 2.6、3.2、3.3、7.3 和 8 nM。它在体内表现出抗抑郁和抗焦虑作用。

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Zotepine

一键复制产品信息

很棒

纯度: 99.78%

货号 T19680 别名 佐替平Cas号 26615-21-4

规格	价格	库存
1 mg	¥ 388	现货
5 mg	¥ 747	现货
10 mg	¥ 969	现货
25 mg	¥ 1,380	现货
50 mg	¥ 1,980	现货
100 mg	¥ 3,120	现货
200 mg	¥ 4,470	现货
1 mL x 10 mM (in DMSO)	¥ 788	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.78%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Zotepine AI Summary

Zotepine exhibits a diverse range of bioactivities and binding affinities towards various human receptors, including dopamine receptors (DRD1, DRD2, DRD3, and DRD4), serotonin receptors (5-HT2A, 5-HT2C, and 5-HT1), alpha adrenergic receptors (alpha-1 and alpha-2), and histamine H1 receptor. It shows very high binding affinity towards human serotonin 5-HT2A receptor (Ki = 0.5 nM) and strong binding affinity to dopamine D2 (Ki = 11.0 nM), D3 (Ki = 6.4 nM), and histamine H1 receptor (Ki = 0.62 nM). It also exhibits moderate binding affinity towards these receptors and others such as D1 (Ki = 29.0 nM), D4 (Ki = 39.0 nM), and alpha-2 adrenergic receptor (Ki = 180.0 nM), but lower binding affinity towards muscarinic receptor. Additionally, Zotepine affects neurotransmission and receptor-mediated activities, as well as demonstrating significant engagement in various biological assays. It has exhibited inhibitory activity against human tyrosyl-DNA phosphodiesterase 1 (TDP1) and demonstrated potential antiviral effects against Lassa Virus, Marburg Virus, Ebola Virus, and SARS-CoV-2, albeit with varying degrees of efficacy. Notably, it displays inhibitory activity against SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells, though with limited potency. Zotepine also shows strong inhibition of human HDAC6 enzyme activity, with an IC50 value of 602.4 nM, and possesses moderate liver toxicity as indicated by elevated levels of ALT and AST serum activities in clinical trials. Furthermore, it has been evaluated in numerous receptor, enzyme, and transporter assays, demonstrating a wide range of interactions and activities that may inform its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
靶点活性	H1 receptor:3.3 nM(Kd), 5-HT2A:2.6 nM(Kd), 5-HT2C:3.2 nM(Kd)
别名	佐替平

化学信息

分子量	331.86
分子式	C₁₈H₁₈ClNOS
CAS No.	26615-21-4
Smiles	CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc12
密度	1.0675 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (75.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0133 mL	15.0666 mL	30.1332 mL	150.6659 mL
5 mM	0.6027 mL	3.0133 mL	6.0266 mL	30.1332 mL
10 mM	0.3013 mL	1.5067 mL	3.0133 mL	15.0666 mL
20 mM	0.1507 mL	0.7533 mL	1.5067 mL	7.5333 mL
50 mM	0.0603 mL	0.3013 mL	0.6027 mL	3.0133 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Zotepine

Zotepine

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Zotepine

Zotepine

Zotepine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词