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3-Indolepropionic acid

Name: 3-Indolepropionic acid
Brand: TargetMol
SKU: T5297
Price: 126 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 吲哚-3-丙酸, IPA, Indolepropionic acid, indole-3-propionic acid

货号 T5297Cas号 830-96-6 一键复制产品信息纯度: 99.94%

很棒

3-Indolepropionic acid (Indolepropionic acid) 是强效的抗氧化剂，具有研究阿尔兹海默症的潜能。

3-Indolepropionic acid

一键复制产品信息

很棒

纯度: 99.94%

货号 T5297Cas号 830-96-6

别名 吲哚-3-丙酸, IPA, Indolepropionic acid, indole-3-propionic acid

3-Indolepropionic acid (Indolepropionic acid) 是强效的抗氧化剂，具有研究阿尔兹海默症的潜能。

规格	价格	库存
100 mg	¥ 126	现货
500 mg	¥ 263	现货
1 g	¥ 406	现货
2 g	¥ 586	现货
5 g	¥ 960	现货
10 g	¥ 1,400	现货
1 mL x 10 mM (in DMSO)	¥ 297	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: ≥95%

颜色: 白色至黄色

性状: Solid

资源下载: COA HNMR产品操作手册

产品介绍

3-Indolepropionic acid AI Summary

3-Indolepropionic acid exhibits a variety of biological activities and properties. It has notable antioxidant properties, demonstrating hydroxyl radical scavenging activity at 1 µmol/mL with an activity of 95.7 nM and radical reducing potency with an activity of 96.5 nM. The compound inhibits hydrogen peroxide, peroxynitrite, and doxorubicin-induced cell death in mixed cortical cells of E15 Sprague-Dawley rat embryos at 10 µM, with respective inhibitions of 87.7%, 83.8%, and 76.1%. Additionally, it protects rotifers from hydrogen peroxide and doxorubicin toxicity at the same concentration, with activities of 67.9% and 53.8%. 3-Indolepropionic acid has a high permeability coefficient indicated by a LogP app value of -5.68 and a partition coefficient with a LogP value of 1.75. It inhibits human recombinant KAT1 with an IC50 of 140,000 nM and shows antagonist activity at the human T1R2/T1R3 receptor, with an IC50 value > 1,000,000 nM for sucralose-induced calcium mobilization inhibition. In terms of antiviral properties, 3-Indolepropionic acid inhibits SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM, though with variable efficacy (-17.48% and -0.15% inhibition, respectively). It also inhibits the SARS-CoV-2 3CL-Pro protease by 10.15% at 20 µM. Moreover, 3-Indolepropionic acid exhibits antitubercular activity with a MIC50 of 68,000 nM against Mycobacterium tuberculosis and shows oral bioavailability of 30% in CD-1 mice at 100 mg/kg. It reduces bacterial load in infected mouse spleen with a fold change of 7.0 at the same dosage administered orally 6 days per week for 4 weeks. The compound also shows modest inhibition (6.28% and -8.28%) in an enzymatic assay of human HDAC6 using peptide substrates. In summary, 3-Indolepropionic acid displays multifaceted bioactivity, including antioxidant, antiviral, and antitubercular properties, alongside notable permeability and solubility characteristics..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-Indolepropionic acid (Indolepropionic acid) is shown to be a powerful antioxidant with potential in the treatment for Alzheimer’s disease.
别名	吲哚-3-丙酸, IPA, Indolepropionic acid, indole-3-propionic acid

化学信息

分子量	189.21
分子式	C₁₁H₁₁NO₂
CAS No.	830-96-6
Smiles	O=C(O)CCC1=CNC=2C=CC=CC21
密度	0.960 g/mL at 20°C

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (528.51 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

Ethanol: 50 mg/mL (264.26 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (21.14 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2851 mL	26.4257 mL	52.8513 mL	264.2566 mL
5 mM	1.0570 mL	5.2851 mL	10.5703 mL	52.8513 mL
10 mM	0.5285 mL	2.6426 mL	5.2851 mL	26.4257 mL
20 mM	0.2643 mL	1.3213 mL	2.6426 mL	13.2128 mL
50 mM	0.1057 mL	0.5285 mL	1.0570 mL	5.2851 mL
100 mM	0.0529 mL	0.2643 mL	0.5285 mL	2.6426 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

ReactiveOxygenSpecies Reactive Oxygen Species Inhibitor inhibit EndogenousMetabolite Endogenous Metabolite Antioxidant 3-IPA 3-Indolepropionic acid 3Indolepropionic acid 3 Indolepropionic acid

3-Indolepropionic acid

3-Indolepropionic acid