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D-Histidine

Name: D-Histidine
Brand: TargetMol
SKU: T9372
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.57%

货号 T9372Cas号 351-50-8

D-Histidine 是一种 L-histidine 的对映体。其中 L-histidine 是婴儿必需的氨基酸，是一种线粒体谷氨酰胺转运的抑制剂。

D-Histidine

一键复制产品信息

很棒

纯度: 99.57%

货号 T9372Cas号 351-50-8

D-Histidine 是一种 L-histidine 的对映体。其中 L-histidine 是婴儿必需的氨基酸，是一种线粒体谷氨酰胺转运的抑制剂。

规格	价格	库存	数量
1 g	¥ 99	现货
5 g	¥ 150	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.

化学信息

分子量	155.15
分子式	C₆H₉N₃O₂
CAS No.	351-50-8
Smiles	N[C@H](Cc1c[nH]cn1)C(O)=O
密度	1.3092 g/cm3 (Estimated)
颜色	White
物理性状	solid

储存&溶解度

存储

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 31.2 mg/mL (201.1 mM), Sonication and heating are recommended.

DMSO: < 1.55 mg/mL (10 mM, insoluble or slightly soluble)

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.4454 mL	32.2269 mL	64.4538 mL	322.2688 mL
5 mM	1.2891 mL	6.4454 mL	12.8908 mL	64.4538 mL
10 mM	0.6445 mL	3.2227 mL	6.4454 mL	32.2269 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.3223 mL	1.6113 mL	3.2227 mL	16.1134 mL
50 mM	0.1289 mL	0.6445 mL	1.2891 mL	6.4454 mL
100 mM	0.0645 mL	0.3223 mL	0.6445 mL	3.2227 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

D-Histidine exhibits diverse bioactivities, notably in modulating carbonic anhydrase (CA) enzymes and exhibiting antiviral properties. It acts as a potent activator for several human CA isoforms, including CA1 with a KA value of 0.09 uM, CA5A with a KA value of 0.12 uM, and CA13 also with a KA value of 0.09 uM. Moderate activation was observed for CA3 (KA of 1.1 uM), CA7 (KA of 0.71 uM), and CA14 (KA of 2.4 uM), while lower affinities were noted for CA2 (KA of 43.0 uM), CA4 (KA of 12.3 uM), and CA5B (KA of 4.38 uM). The compound also shows inhibitory activity against human carbonic anhydrase 1 (KA of 0.09 uM) and CA2 (KA of 43.0 uM). Additionally, D-Histidine exhibits antiviral activity, particularly against SARS-CoV-2. It reduces virus-induced cytotoxicity in Vero-6 cells and demonstrates some degree of inhibition against the SARS-CoV-2 3CL-Pro protease. Furthermore, the compound shows inhibition of the human LAT1 transporter in TREx HEK293 cells with an IC50 value of 460000.0 nM and inhibition of the human HDAC6 enzyme with variable percentages depending on the substrate used. Overall, D-Histidine displays a broad spectrum of biological activities, making it a versatile candidate for therapeutic exploration..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl