Name: Pemetrexed disodium heptahydrate
Brand: TargetMol
SKU: T66032
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

5 mg

¥ 198

现货

10 mg

¥ 288

现货

25 mg

¥ 469

现货

50 mg

¥ 683

现货

100 mg

¥ 987

现货

500 mg

¥ 2,590

现货

生物活性

产品描述	Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC).
靶点活性	TS:1.3 nM (Ki), GARFT:65 nM (Ki), DHFR:7.2 nM (Ki)
体内活性	生存分析结果显示，接受PC61联合Pemetrexed disodium heptahydrate治疗的小鼠存活时间明显长于仅接受PC61治疗、大鼠IgG联合Pemetrexed disodium heptahydrate治疗以及未接受任何治疗的小鼠。[2]
别名	培美曲塞二钠七水合物

化学信息

分子量	597.49
分子式	C₂₀H₃₃N₅Na₂O₁₃
CAS No.	357166-29-1
Smiles	O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 80 mg/mL (133.89 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6737 mL	8.3683 mL	16.7367 mL	83.6834 mL
5 mM	0.3347 mL	1.6737 mL	3.3473 mL	16.7367 mL
10 mM	0.1674 mL	0.8368 mL	1.6737 mL	8.3683 mL
20 mM	0.0837 mL	0.4184 mL	0.8368 mL	4.1842 mL
50 mM	0.0335 mL	0.1674 mL	0.3347 mL	1.6737 mL
100 mM	0.0167 mL	0.0837 mL	0.1674 mL	0.8368 mL