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Steviol

Name: Steviol
Brand: TargetMol
SKU: T2S1837
Price: 312 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T2S1837Cas号 471-80-7

别名 甜菊醇, NSC 226902, Hydroxydehydrostevic acid

Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。

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Steviol

一键复制产品信息

很棒

纯度: 99.92%

货号 T2S1837 别名 甜菊醇, NSC 226902, Hydroxydehydrostevic acidCas号 471-80-7

Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。

规格	价格	库存
1 mg	¥ 312	现货
5 mg	¥ 787	现货
10 mg	¥ 1,310	现货
25 mg	¥ 2,360	现货
50 mg	¥ 3,210	现货
100 mg	¥ 4,570	现货
200 mg	¥ 6,330	现货
1 mL x 10 mM (in DMSO)	¥ 549	现货

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纯度: 98.61%

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COA HPLC HNMR 产品操作手册

产品介绍

Steviol AI Summary

Steviol shows a diverse range of biological activities. It functions as an inhibitor of HIV1 Reverse Transcriptase, with an IC50 value greater than 200.0 µg/mL. The compound also inhibits TPA-induced EBV-early antigen activation in human Raji cells and demonstrates cytotoxicity at multiple mol ratios. In mouse models, it reduces DMBA-induced/TPA-promoted skin papillomas and shows inhibitory effects on peroxynitrite-induced/TPA-promoted carcinogenesis in Sencar mice. Steviol acts as an agonist at the glucocorticoid receptor in mouse RAW264.7 cells, assessed by a dual luciferase reporter assay with a firefly/renilla luciferase ratio of 1.45 at 10 µM. It displays bioactivity as a potential inhibitor of mitochondrial division or activator of mitochondrial fusion with a potency of 20596.2 nM and as an inhibitor of Histone Lysine Methyltransferase G9a with a potency of 31622.8 nM. The compound exhibits antiviral activity against Hepatitis B virus in human HuH7 cells, inhibiting viral DNA replication and HBeAg secretion with IC50 values of 19900.0 nM and 16600.0-20800.0 nM, respectively, and a TC50 value of 474.5 µM. In terms of antiproliferative activity, it has an IC50 value of 185,000.0 nM in human MCF7 cells and shows IC50 values greater than 10,000 nM in various other human cell lines such as A549, HCT-116, HeLa, Huh-7, and MDA-MB-231..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.

别名

甜菊醇, NSC 226902, Hydroxydehydrostevic acid

化学信息

分子量	318.45
分子式	C₂₀H₃₀O₃
CAS No.	471-80-7
Smiles	C[C@]12CCC[C@](C)([C@@H]1CC[C@]13CC(=C)[C@@](O)(C1)CC[C@H]23)C(O)=O
密度	1.17 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (392.53 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.28 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1402 mL	15.7011 mL	31.4021 mL	157.0105 mL
5 mM	0.6280 mL	3.1402 mL	6.2804 mL	31.4021 mL
10 mM	0.3140 mL	1.5701 mL	3.1402 mL	15.7011 mL
20 mM	0.1570 mL	0.7851 mL	1.5701 mL	7.8505 mL
50 mM	0.0628 mL	0.3140 mL	0.6280 mL	3.1402 mL
100 mM	0.0314 mL	0.1570 mL	0.3140 mL	1.5701 mL