Cephalotaxine

Name: Cephalotaxine
Brand: TargetMol
SKU: T3366
Price: 138 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.15%

货号 T3366Cas号 24316-19-6

别名 三尖杉碱, ZINC19795976, Cephalotaxlen, (-)-Cephalotaxine

Cephalotaxine (ZINC19795976) 是从头孢紫杉中分离得到的一种生物碱，具有抗白血病和抗病毒活性，如抗 Zika 病毒。

Cephalotaxine

一键复制产品信息

很棒

纯度: 99.15%

货号 T3366 别名 三尖杉碱, ZINC19795976, Cephalotaxlen, (-)-CephalotaxineCas号 24316-19-6

Cephalotaxine (ZINC19795976) 是从头孢紫杉中分离得到的一种生物碱，具有抗白血病和抗病毒活性，如抗 Zika 病毒。

规格	价格	库存
25 mg	¥ 193	现货
50 mg	¥ 276	现货
100 mg	¥ 398	现货
1 mL x 10 mM (in DMSO)	¥ 138	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.05%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

Cephalotaxine AI Summary

Cephalotaxine inhibits protein synthesis in cell-free lysates with an IC50 value of 440,000,000 nM. It also inhibits anisomycin-induced p38 phosphorylation in human U937 cells with an IC50 of 200 nM and exhibits inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation by more than 65% at 20 μM, while its inhibition of JAK-mediated GM-CSF-induced Stat5 phosphorylation is only 25% at the same concentration. Additionally, Cephalotaxine shows high inhibitory effects on sodium fluorescein uptake in both OATP1B1-transfected and OATP1B3-transfected CHO cells, with inhibition rates of 77.26% and 77.89%, respectively, at 10 μM. It demonstrates bioactivity as an inhibitor of binding or entry into cells for the Marburg Virus with a potency of 6309.6 nM and shows antiproliferative activity against human HL60 cells with an IC50 of 61200 nM after 62 hours, based on the MTS assay. Furthermore, it exhibits antiproliferative activity against human K562, HL-60, and U-937 cells, with an IC50 value greater than 30000 nM for all three cell lines after 72 hours of treatment, indicating moderate to weak inhibitory potency..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cephalotaxine (ZINC19795976) is an antiviral and an antitumor agent.
别名	三尖杉碱, ZINC19795976, Cephalotaxlen, (-)-Cephalotaxine

化学信息

分子量	315.36
分子式	C₁₈H₂₁NO₄
CAS No.	24316-19-6
Smiles	COC1=C[C@]23CCCN2CCc2cc4OCOc4cc2[C@@H]3[C@@H]1O
密度	1.38 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 47 mg/mL (149.04 mM), Sonication is recommended.

Chloroform: Soluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.34 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1710 mL	15.8549 mL	31.7098 mL	158.5490 mL
5 mM	0.6342 mL	3.1710 mL	6.3420 mL	31.7098 mL
10 mM	0.3171 mL	1.5855 mL	3.1710 mL	15.8549 mL
20 mM	0.1585 mL	0.7927 mL	1.5855 mL	7.9274 mL
50 mM	0.0634 mL	0.3171 mL	0.6342 mL	3.1710 mL
100 mM	0.0317 mL	0.1585 mL	0.3171 mL	1.5855 mL