Rineterkib hydrochloride

Name: Rineterkib hydrochloride
Brand: TargetMol
SKU: T36676
Rating: 4.5 (1 reviews)

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产品编号 T36676Cas号 1715025-34-5

Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1].

Rineterkib hydrochloride

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产品编号 T36676Cas号 1715025-34-5

规格	价格	库存	数量
25 mg	¥ 7,890	待询

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产品介绍

生物活性

产品描述	Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1].
体外活性	ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1].

化学信息

分子量	614.89
分子式	C₂₆H₂₈BrClF₃N₅O₂
CAS No.	1715025-34-5

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 220 mg/mL (357.79 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6263 mL	8.1315 mL	16.2631 mL	81.3154 mL
5 mM	0.3253 mL	1.6263 mL	3.2526 mL	16.2631 mL
10 mM	0.1626 mL	0.8132 mL	1.6263 mL	8.1315 mL
20 mM	0.0813 mL	0.4066 mL	0.8132 mL	4.0658 mL
50 mM	0.0325 mL	0.1626 mL	0.3253 mL	1.6263 mL
100 mM	0.0163 mL	0.0813 mL	0.1626 mL	0.8132 mL