规格

价格

库存

数量

1 mg

¥ 619

现货

5 mg

¥ 1,490

现货

10 mg

¥ 2,650

现货

25 mg

¥ 4,350

现货

50 mg

¥ 6,150

现货

100 mg

¥ 8,280

现货

500 mg

¥ 16,500

现货

生物活性

产品描述	LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
体外活性	在大鼠原代小胶质细胞中，LQVTDSGLYRCVIYHPP（100 nM，预处理1小时）显著抑制血红蛋白诱导的炎症反应，降低了TREM-1、TNF-α、IL-1β、IL-6 和 iNOS 的表达，减少了NO生成，并抑制了NF-κB p65 的核转位，显示出明确的抗炎作用[1]。
体内活性	在蛛网膜下腔出血（SAH）模型大鼠中，脑室注射 LQVTDSGLYRCVIYHPP（0.5 μg）显著抑制TREM-1和炎症因子的表达，减少神经元凋亡，并改善神经行为评分，表明其具有良好的抗炎与神经保护作用[1]。
别名	LP17

化学信息

分子量	1961.24
分子式	C₈₉H₁₃₇N₂₃O₂₅S
CAS No.	887255-16-5
Smiles	C(=O)([C@H]1N(C([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCC(N)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CS)=O)[C@H](C)C)=O)[C@H](CC)C)=O)=O)=O)CCC1)N5[C@H](C(O)=O)CCC5
Sequence	Leu-Gln-Val-Thr-Asp-Ser-Gly-Leu-Tyr-Arg-Cys-Val-Ile-Tyr-His-Pro-Pro
Sequence Short	LQVTDSGLYRCVIYHPP

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 10 mg/mL (5.1 mM), when pH is adjusted to 3 with CH3COOH. Sonication and heating are recommended.

DMSO: 15 mg/mL (7.65 mM), when pH is adjusted to 7 with CH3COOH. Sonication and heating are recommended.

溶液配制表

H2O/DMSO