Amifampridine

Name: Amifampridine
Brand: TargetMol
SKU: T4497
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.82%

货号 T4497Cas号 54-96-6

别名 阿米吡啶, Pyridine-3,4-Diamine, 3,4-Pyridinediamine, 3,4-Diaminopyridine

Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。

Amifampridine

一键复制产品信息

很棒

纯度: 99.82%

货号 T4497 别名 阿米吡啶, Pyridine-3,4-Diamine, 3,4-Pyridinediamine, 3,4-DiaminopyridineCas号 54-96-6

Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.82%

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COA HNMR LCMS 产品操作手册

产品介绍

Amifampridine AI Summary

Amifampridine exhibits a diverse range of bioactivities. Primarily, the compound selectively increases both basal and K+-stimulated acetylcholine (AcCh) release across various brain regions, including the hippocampus, cortex, and striatum, with dose-dependent effects in these areas. Additionally, it inhibits [3H]choline uptake at choline transporter 1 in mouse brain synaptosomes with a Ki value of 820351.54 nM. Beyond its impact on neurotransmitter release, Amifampridine demonstrates inhibitory activities against multiple targets such as lipid storage, AmpC beta-lactamase, histone lysine methyltransferase G9a, and several others, with potencies in the nanomolar to micromolar range. The compound also shows antiviral properties, including inhibition of cytotoxicity induced by SARS-CoV-2 in various cell lines and inhibition of the SARS-CoV-2 3CL-Pro protease. However, its effectiveness against SARS-CoV-2 is limited, with an IC50 value greater than 20000.0 nM and variable inhibition percentages. Additionally, the compound exhibits notable activity in an enzymatic assay of human HDAC6 and functions as a substrate for human OCT1, characterized by specific kinetic parameters and intrinsic clearance values. Despite these activities, Amifampridine has shown no significant bioactivity in binding affinity and inhibition assays against several human and rat receptors, enzymes, and ion channels, with all AC50 values exceeding 30,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate.
别名	阿米吡啶, Pyridine-3,4-Diamine, 3,4-Pyridinediamine, 3,4-Diaminopyridine

化学信息

分子量	109.13
分子式	C₅H₇N₃
CAS No.	54-96-6
Smiles	NC1=C(N)C=NC=C1
密度	1.251g/cm3
颜色	Red
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 24 mg/mL (219.92 mM), Sonication is recommended.

DMSO: 60 mg/mL (549.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (18.33 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	9.1634 mL	45.8169 mL	91.6338 mL	458.1692 mL
5 mM	1.8327 mL	9.1634 mL	18.3268 mL	91.6338 mL
10 mM	0.9163 mL	4.5817 mL	9.1634 mL	45.8169 mL
20 mM	0.4582 mL	2.2908 mL	4.5817 mL	22.9085 mL
50 mM	0.1833 mL	0.9163 mL	1.8327 mL	9.1634 mL
100 mM	0.0916 mL	0.4582 mL	0.9163 mL	4.5817 mL