hAChE-IN-1 (Compound 24) is a potent inhibitor of human acetylcholinesterase (hAChE), exhibiting an inhibition concentration half-maximum (IC50) of 1.09 μM. Additionally, it inhibits tau-oligomerization with an effective concentration half-maximum (EC50) of 2.71 μM as determined by a cellular tau fluorescence resonance energy transfer (FRET) assay [1].

AChE (human):1.09 μM, Tau-oligomerization:2.71 μM (EC50)

hAChE-IN-1（化合物24；1-10 μM；24小时）对转染野生型tau蛋白的SH-SY5Y细胞显示出神经保护效果[1]。