DHQZ 36 causes over 40% reduction in secreted of parasite proteins and it also causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation. With increasing concentrations of DHQZ 36, there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM.