2'-Fluoro-2'-Deoxyadenosine

Name: 2'-Fluoro-2'-Deoxyadenosine
Brand: TargetMol
SKU: T9727
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.95%

货号 T9727Cas号 64183-27-3

别名 2'-氟-2'-脱氧腺苷

2′-Deoxy-2′-fluoroadenosine 可用于合成2 ' -脱氧-2 ' -氟修饰的寡核苷酸。它能被大肠杆菌嘌呤核苷磷酸化酶（PNP）有效地分解成毒性物 2-氟腺嘌呤，对表达大肠杆菌 PNP 的肿瘤表现出良好的体内活性。

2'-Fluoro-2'-Deoxyadenosine

一键复制产品信息

很棒

纯度: 99.95%

货号 T9727 别名 2'-氟-2'-脱氧腺苷Cas号 64183-27-3

规格	价格	库存	数量
100 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.95%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

2'-Fluoro-2'-Deoxyadenosine AI Summary

2'-Fluoro-2'-Deoxyadenosine exhibits a broad spectrum of biological activities. It shows antiviral activity against Influenza virus (A/Sweden/3/50/(H1N1)) in dog kidney (MDCK) cells with an IC50 of 52000 nM, though it also demonstrates cytotoxicity in uninfected MDCK cells with an IC50 of 320000 nM. The compound lacks significant activity in inhibiting HCV NS5B-mediated RNA synthesis and HCV RNA replication with an IC50 and EC50 both exceeding 50000 nM. However, it does exhibit notable anti-HBV activity in HepG2 2.2.15 cells with an EC50 of 1500 nM, showing low cytotoxicity in these cells (IC50 > 200000 nM) and moderate cytotoxicity in CEM cells (IC50 = 90000 nM). Additionally, 2'-Fluoro-2'-Deoxyadenosine inhibits the growth of Trichomonas vaginalis T1 with an IC50 of 2940 nM, achieving 100% growth inhibition at a concentration of 100 µM. It also inhibits RSV A2 RNA-dependent RNA polymerase with an IC50 of 7700 nM but has an EC50 greater than 50000 nM in RSV A2-infected human Hep2 cells. The compound impacts human mitochondrial RNA polymerase and DNA polymerase gamma by 24% and 8%, respectively. Various assays indicate hepatotoxic and nephrotoxic effects, alongside alterations in blood composition and electrolyte balance. These diverse bioactivities suggest the need for careful consideration of 2'-Fluoro-2'-Deoxyadenosine's therapeutic potentials and toxicological profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
别名	2'-氟-2'-脱氧腺苷

化学信息

分子量	269.23
分子式	C₁₀H₁₂FN₅O₃
CAS No.	64183-27-3
Smiles	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
密度	2.01 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (185.71 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.43 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7143 mL	18.5715 mL	37.1430 mL	185.7148 mL
5 mM	0.7429 mL	3.7143 mL	7.4286 mL	37.1430 mL
10 mM	0.3714 mL	1.8571 mL	3.7143 mL	18.5715 mL
20 mM	0.1857 mL	0.9286 mL	1.8571 mL	9.2857 mL
50 mM	0.0743 mL	0.3714 mL	0.7429 mL	3.7143 mL
100 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8571 mL