Powder: -20°C for 3 years | In solvent: -80°C for 1 year
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = <500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 μg | ¥ 192 | 35日内发货 | ||
1 mg | ¥ 315 | 35日内发货 | ||
5 mg | ¥ 1,220 | 35日内发货 | ||
10 mg | ¥ 2,100 | 35日内发货 |
产品描述 | D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. |
分子量 | 361.56 |
分子式 | C23H39NO2 |
CAS No. | 143492-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 0.1 mg/mL
Ethanol: 20 mg/mL
DMF: 20 mg/mL
Ethanol:PBS (pH 7.2) (1:2): 0.5 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
D-erythro-MAPP 143492-38-0 D erythro MAPP DerythroMAPP Inhibitor inhibitor inhibit