很棒SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
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很棒SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 1,160 | 现货 | |
| 5 mg | ¥ 2,970 | 现货 | |
| 10 mg | ¥ 4,290 | 现货 | |
| 25 mg | ¥ 6,690 | 现货 | |
| 50 mg | ¥ 8,870 | 现货 | |
| 100 mg | ¥ 12,200 | 现货 | |
| 200 mg | ¥ 16,300 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,390 | 现货 |
| 产品描述 | SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease. |
| 体外活性 | SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1]. |
| 体内活性 | SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1]. |
| 别名 | SC-D |
| 分子量 | 354.2 |
| 分子式 | C13H5F3N4O5 |
| CAS No. | 685121-45-3 |
| Smiles | [O-][N+](=O)c1cccc(c1)-c1[nH]c(=O)c(C#N)c(c1[N+]([O-])=O)C(F)(F)F |
| 密度 | 1.68 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 45 mg/mL (127.05 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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