4'-Hydroxychalcone

Name: 4'-Hydroxychalcone
Brand: TargetMol
SKU: T7917
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T7917Cas号 2657-25-2

别名 4-羟基查耳酮, 4′-羟基查耳酮, 2-Benzal-4-Hydroxyacetophenone

4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮，具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾，并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome)，抑制TNFα 诱导的 NF-κB 活性。

4'-Hydroxychalcone

一键复制产品信息

很棒

纯度: 99.87%

货号 T7917 别名 4-羟基查耳酮, 4′-羟基查耳酮, 2-Benzal-4-HydroxyacetophenoneCas号 2657-25-2

规格	价格	库存
500 mg	¥ 136	现货
5 g	¥ 413	现货
1 mL x 10 mM (in DMSO)	¥ 205	现货

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纯度: 99.87%

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产品介绍

4'-Hydroxychalcone AI Summary

4'-Hydroxychalcone exhibits a broad range of bioactivities across different biological systems and targets. It acts as a growth inhibitor of chloroquine-resistant Plasmodium falciparum K1 with an IC50 of 29600.0 nM and shows substantial inhibitory effects on Interleukin-1-beta production in human monocytes (IC50 = 6130.0 nM) and Leishmania donovani in vitro (IC50 = 16000.0 nM). Additionally, 4'-Hydroxychalcone inhibits the enzyme activities of hamster liver aldehyde dehydrogenase ALDH-2 (IC50 = 7000.0 nM) and mitochondrial monoamine oxidase MAO (IC50 = 4500.0 nM). In cellular assays, it demonstrates anti-proliferative properties with varying IC50 values against murine P388 cells, L1210 leukemia cells, human Molt 4/C8 T-lymphocyte cells, and Human CEM T-lymphocytes cells. It also induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells (16.0 μM concentration). 4'-Hydroxychalcone exhibits inhibitory action against recombinant rat androgen receptors (IC50 = 57543.99 nM) and human tyrosyl-DNA phosphodiesterase 1 (TDP1). Furthermore, 4'-Hydroxychalcone shows a high affinity for enzymes involved in inflammatory pathways, such as cyclooxygenase and 5-lipoxygenase, and demonstrates inhibition of lipid peroxidation in rat liver microsomes. It has significant bioactivity as a larvicide against Culex quinquefasciatus, with an LC50 of 238.0 μmol/dm³, and exhibits pronounced antifungal activity against fluconazole-resistant Candida albicans. Moreover, 4'-Hydroxychalcone shows significant inhibitory activity against human MAOB (IC50 = 182.0 nM), with high selectivity over MAOA, and demonstrates antioxidant properties such as DPPH and ABTS radical scavenging activities. It also inhibits specific chaperone proteins in E. coli and human mitochondrial cells while affecting the ATPase activity of Escherichia coli GroEL. Lastly, the compound shows potential as a candidate for further studies due to its potency in various assays related to anti-coagulant, anti-inflammatory, antioxidant, and cytotoxic properties in different biological systems..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity
别名	4-羟基查耳酮, 4′-羟基查耳酮, 2-Benzal-4-Hydroxyacetophenone

化学信息

分子量	224.25
分子式	C₁₅H₁₂O₂
CAS No.	2657-25-2
Smiles	OC1=CC=C(C=C1)C(=O)\C=C\C1=CC=CC=C1
密度	1.191 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (222.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4593 mL	22.2965 mL	44.5931 mL	222.9654 mL
5 mM	0.8919 mL	4.4593 mL	8.9186 mL	44.5931 mL
10 mM	0.4459 mL	2.2297 mL	4.4593 mL	22.2965 mL
20 mM	0.2230 mL	1.1148 mL	2.2297 mL	11.1483 mL
50 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
100 mM	0.0446 mL	0.2230 mL	0.4459 mL	2.2297 mL