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VU590

Name: VU590
Brand: TargetMol
SKU: T23516
Price: 266 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.06%

货号 T23516Cas号 313505-85-0

VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1，可调节子宫肌层收缩力和黑皮质素信号传导。

VU590

一键复制产品信息

很棒

纯度: 98.06%

货号 T23516Cas号 313505-85-0

VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1，可调节子宫肌层收缩力和黑皮质素信号传导。

规格	价格	库存
1 mg	¥ 266	现货
5 mg	¥ 619	现货
10 mg	¥ 993	现货
25 mg	¥ 1,650	现货
50 mg	¥ 2,480	现货
100 mg	¥ 3,730	现货
500 mg	¥ 7,850	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.06%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

VU590 AI Summary

VU590 exhibits a diverse range of bioactivities, making it a versatile candidate for various biomedical applications. It shows significant inhibitory activity against several targets including ROMK with an IC50 of 290 nM, rat ROMK1 in HEK293 cells with an IC50 of 294 nM, and human Kir7.1 with 69% inhibition at 10 µM. Additionally, it potently modulates Lamin A splicing, enhances SMN2 splice variant expression, and inhibits Tau fibril formation. VU590 also inhibits various enzymes and proteins such as Aldehyde Dehydrogenase 1 (ALDH1A1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), JMJD2A-Tudor domain, Nrf2, Histone Lysine Methyltransferase G9a, BAZ2B, TGF-β, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). The compound also shows bioactivities that include inhibiting the binding or entry into cells of Lassa Virus, Marburg Virus, and Hepatitis C Virus (HCV), and inducing synthetic lethality in tumor cells producing 2HG. It is also noted for its potential in antimalarial drug lead development by inhibiting AMA1-RON and MBNL1-poly(CUG) RNA binding, and for antiviral activity noted by a high throughput screening for Foot and Mouth Disease Virus antivirals. Additionally, VU590 exhibits moderate antiviral activity against SARS-CoV-2, including inhibition of the SARS-CoV-2 3CL-Pro protease (13.58% inhibition at 20 µM) and inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM. Lastly, it shows cytotoxic activity against human HepG2 cells with an IC50 of 10400 nM as per the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
靶点活性	Kir7.1:8 μM, Kir1.1:290 nM

化学信息

分子量	488.53
分子式	C₂₄H₃₂N₄O₇
CAS No.	313505-85-0
Smiles	Cl.Cl.[O-][N+](=O)c1ccc(CN2CCOCCOCCN(Cc3ccc(cc3)[N+]([O-])=O)CCOCC2)cc1
密度	1.216 g/cm3 (Predicted)

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 20 mg/mL, Sonication is recommended.

H2O: 1 mg/mL (2.05 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0470 mL	10.2348 mL	20.4696 mL	102.3479 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

VU-590 (hydrochloride)VU590 (hydrochloride)VU-590 VU590 VU 590 ROMK PotassiumChannel Potassium Channel Kir1.1

VU590

VU590

VU590 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词