规格

价格

库存

数量

1 mg

¥ 495

现货

5 mg

¥ 1,190

现货

10 mg

¥ 1,760

现货

25 mg

¥ 2,970

现货

50 mg

¥ 4,380

待询

100 mg

¥ 6,250

待询

生物活性

产品描述	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.
体外活性	Qingyangshengenin B（Ot B）能够适度延长秀丽隐杆线虫（C. elegans）的寿命，延缓身体运动能力随年龄衰减的速度，并提高其抗压力能力。进一步研究寿命延长效应的分子机制显示，Ot B能激活FOXO转录因子DAF-16。对于寿命已经通过胰岛素/IGF-1样受体（daf-2）突变体延长的线虫，Ot B无法进一步延长其寿命。此外，Ot B的寿命延长效应还依赖于SIR-2.1和参与泛醌合成的酶CLK-1。
别名	青阳参苷元B, 青阳参甙元B, Otophylloside B

化学信息

分子量	923.13
分子式	C₄₉H₇₈O₁₆
CAS No.	106758-54-7
Smiles	O[C@]12[C@](C)([C@H](OC(/C=C(/C(C)C)\C)=O)C[C@]3([C@@]1(O)CC=C4[C@]3(C)CC[C@H](O[C@H]5C[C@H](OC)[C@H](O[C@H]6C[C@H](OC)[C@H](O[C@H]7C[C@@H](OC)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)C4)[H])[C@@](C(C)=O)(O)CC2
密度	1.26 g/cm3 at 20℃
颜色	White
物理性状	Solid