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Oxypurinol

Name: Oxypurinol
Brand: TargetMol
SKU: T1694
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.96%

货号 T1694Cas号 2465-59-0

别名 羟基嘌呤, Oxipurinol

Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。

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Oxypurinol

一键复制产品信息

很棒

纯度: 99.96%

货号 T1694 别名 羟基嘌呤, OxipurinolCas号 2465-59-0

Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。

规格	价格	库存
2 mg	¥ 127	现货
5 mg	¥ 189	现货
10 mg	¥ 263	现货
25 mg	¥ 496	现货
50 mg	¥ 787	现货
100 mg	¥ 1,170	现货
1 mL x 10 mM (in DMSO)	¥ 288	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

Oxypurinol AI Summary

Oxypurinol is characterized by its bioactivity related to binding energy, with an observed binding energy of 12.6 kcal/mol determined via the equation deltaG obsd = -RT ln KD. It exhibits binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase with a dissociation constant (Kd) of 794328.23 nM, as determined by spectrophotometric analysis. The compound also shows inhibition of AmpC Beta-Lactamase (IC50 = 5011.9 nM), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) (IC50 = 100.0 nM), and induces DNA re-replication in SW480 colon adenocarcinoma cells (IC50 = 1584.9 nM). Moreover, Oxypurinol acts as a potent inhibitor of human xanthine oxidase in both its oxidized form (Ki = 1000.0 nM) and normal form (Ki = 35.0 nM). In terms of antiviral activities, Oxypurinol inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with 5.79% inhibition at 10 µM after 48 hours. It also shows varying degrees of inhibition on SARS-CoV-2 3CL-Pro protease at 20 µM, with inhibition percentages of 11.29%, -1.21%, and -0.8288% in different assay instances. Furthermore, the compound has shown antiviral activity against SARS-CoV-2 in VERO-6 cells, exhibiting inhibition of viral-induced cytotoxicity with varying degrees of effectiveness (0.01% to 0.08% inhibition) at a concentration of 10 µM after 48 hours, and an IC50 value greater than 20000 nM, indicating moderate to low potency..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Oxypurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
别名	羟基嘌呤, Oxipurinol

化学信息

分子量	152.11
分子式	C₅H₄N₄O₂
CAS No.	2465-59-0
Smiles	O=C1NC(=O)C=2C=NNC2N1
密度	2.19g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (65.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.57 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5742 mL	32.8709 mL	65.7419 mL	328.7095 mL
5 mM	1.3148 mL	6.5742 mL	13.1484 mL	65.7419 mL
10 mM	0.6574 mL	3.2871 mL	6.5742 mL	32.8709 mL
20 mM	0.3287 mL	1.6435 mL	3.2871 mL	16.4355 mL
50 mM	0.1315 mL	0.6574 mL	1.3148 mL	6.5742 mL