Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicotredole (Tryptamide) 是一种口服有效的消炎剂,与 Phenylbutazone 的抗炎作用相当。它仅具有弱的致溃疡活性。它可用于缓解疼痛方面的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 328 | 现货 | ||
2 mg | ¥ 483 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,150 | 现货 | ||
50 mg | ¥ 3,320 | 现货 | ||
100 mg | ¥ 4,750 | 现货 | ||
500 mg | ¥ 9,820 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 913 | 现货 |
产品描述 | Nicotredole (Tryptamide) (Tryptamide) is an orally active analgesic and anti-inflammatory agent. Nicotredole exhibits evident anti-inflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity. |
体外活性 | Nicotredole inhibits prostaglandin synthetase activity in vitro assay[1]. |
体内活性 | Nicotredole displays antiinflammatory effects in carrageenin-induced rat paw oedema [1] . Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice [1] . Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively [1] . Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively [1] . Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm 3 ) [2] . |
别名 | Tryptamide, 尼可曲多;尼可曲朵 |
分子量 | 265.31 |
分子式 | C16H15N3O |
CAS No. | 29876-14-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (94.23 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7692 mL | 18.8459 mL | 37.6918 mL | 94.2294 mL |
5 mM | 0.7538 mL | 3.7692 mL | 7.5384 mL | 18.8459 mL | |
10 mM | 0.3769 mL | 1.8846 mL | 3.7692 mL | 9.4229 mL | |
20 mM | 0.1885 mL | 0.9423 mL | 1.8846 mL | 4.7115 mL | |
50 mM | 0.0754 mL | 0.3769 mL | 0.7538 mL | 1.8846 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nicotredole 29876-14-0 Others anti-inflammatory analgesic Tryptamide ulcerogenic inhibit 尼可曲多;尼可曲朵 Inhibitor inhibitor