购物车

您的购物车当前为空

CIL56

Name: CIL56
Brand: TargetMol
SKU: T4309
Price: 240 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.91%

货号 T4309Cas号 300802-28-2

别名 CA3

CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。

为众多的药物研发团队赋能，

让新药发现更简单！

CIL56

一键复制产品信息

很棒

纯度: 99.91%

货号 T4309 别名 CA3Cas号 300802-28-2

CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。

规格	价格	库存
1 mg	¥ 240	现货
2 mg	¥ 351	现货
5 mg	¥ 609	现货
10 mg	¥ 950	现货
25 mg	¥ 1,570	现货
50 mg	¥ 2,560	现货
100 mg	¥ 3,930	现货
1 mL x 10 mM (in DMSO)	¥ 642	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.46%

联系我们获取更多批次信息

资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

CIL56 AI Summary

CIL56 exhibits a wide range of bioactivities, making it a versatile compound for potential drug development and research. Its bioactivities include inhibition of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells, modulation of Lamin A Splicing, and inhibition of HSD17B4 and Human Jumonji Domain Containing 2E (JMJD2E). Additionally, it acts as a modulator of miRNAs and/or activator of miR-21, enhances SMN2 Splice Variant Expression, and serves as an agonist of the Thyroid Stimulating Hormone Receptor. CIL56 also inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) and Heat Shock Factor 1 (HSF1), as well as various enzymes such as Aldehyde Dehydrogenase 1, HPGD, DNA Polymerase Beta. It inhibits ROR gamma transcriptional activity, T-Type Calcium Channel, and ATXN expression, induces DNA re-replication in various cell lines, and inhibits the Hepatitis C Virus (HCV) and various cellular signaling pathways. Notably, CIL56 inhibits Wnt/beta-catenin transcriptional activity in human HT-29 cells with an IC50 value of 990.0 nM, as assessed by TCF luciferase promoter reporter assay. It also shows cytotoxicity against human BJeLR cells overexpressing oncogenic RAS, though with an IC50 value greater than 1000.0 nM. These diverse bioactivities indicate that CIL56 has the potential for affecting numerous cellular processes and pathways, warranting further investigation for therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.

别名

CA3

化学信息

分子量	489.61
分子式	C₂₃H₂₇N₃O₅S₂
CAS No.	300802-28-2
Smiles	ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)N1CCCCC1)S(=O)(=O)N1CCCCC1
密度	1.51 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 6.94 mg/mL (14.17 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0424 mL	10.2122 mL	20.4244 mL	102.1221 mL
5 mM	0.4085 mL	2.0424 mL	4.0849 mL	20.4244 mL
10 mM	0.2042 mL	1.0212 mL	2.0424 mL	10.2122 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

ROS Inhibitor inhibit Ferroptosis CIL-56 CIL56 CIL 56 CA-3 CA 3

CIL56

CIL56

CIL56 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词