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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Decamethonium bromide

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纯度: 99.90%

货号 T0818Cas号 541-22-0

别名 溴化十烃季胺, 十烃溴铵, Syncurine, Decacuran

Decamethonium bromide (Syncurine) 是神经肌肉阻滞剂和烟碱型 AChR 部分激动剂。

Decamethonium bromide
其他形式的 “Decamethonium bromide”:
Decamethonium iodide
Decamethonium chloride
Decamethonium

Decamethonium bromide

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Rating icon 很棒

纯度: 99.90%

货号 T0818 别名 溴化十烃季胺, 十烃溴铵, Syncurine, DecacuranCas号 541-22-0

Decamethonium bromide (Syncurine) 是神经肌肉阻滞剂和烟碱型 AChR 部分激动剂。

规格价格库存数量
100 mg
¥ 133
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500 mg
¥ 280
现货
1 mL x 10 mM (in DMSO)
¥ 338
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产品介绍

生物活性
产品描述
Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.
体内活性

在运动神经肌肉终板,Decamethonium引起去极化,防止从突触前末梢正常释放的乙酰胆碱进一步作用,从而防止神经刺激影响肌肉。在结合过程中,Decamethonium实际上会激活(去极化)运动终板,但其本身不降解,故细胞膜仍然去极化,并对正常的乙酰胆碱释放无反应。作为一种去极化肌肉松弛剂或神经肌肉阻滞剂,Decamethonium被用于麻醉以诱导麻痹。其作用时间短,与乙酰胆碱类似,作为烟碱样乙酰胆碱受体的部分激动剂发挥作用。

别名溴化十烃季胺, 十烃溴铵, Syncurine, Decacuran
化学信息
分子量418.29
分子式C16H38Br2N2
CAS No.541-22-0
Smiles[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
密度no data available
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度信息
H2O: 77 mg/mL (184.08 mM), Sonication is recommended.
DMSO: 65 mg/mL (155.39 mM), Sonication is recommended.
Ethanol: 24 mg/mL (57.38 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.78 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM2.3907 mL11.9534 mL23.9069 mL119.5343 mL
5 mM0.4781 mL2.3907 mL4.7814 mL23.9069 mL
10 mM0.2391 mL1.1953 mL2.3907 mL11.9534 mL
20 mM0.1195 mL0.5977 mL1.1953 mL5.9767 mL
50 mM0.0478 mL0.2391 mL0.4781 mL2.3907 mL
DMSO/H2O
1mg5mg10mg50mg
100 mM0.0239 mL0.1195 mL0.2391 mL1.1953 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Decamethonium bromide exhibits various bioactivities across a broad range of targets and organisms. It shows binding affinity for the nicotinic acetylcholine receptor alpha4-beta2 with a Ki value of 5730.0 nM and considerably lower affinity for the alpha-7 receptor (Ki > 100,000.0 nM). In terms of antiplasmodial activity, the compound displays inhibitory effects against different strains of Plasmodium falciparum, with IC50 values ranging from 398.11 nM to 10,000.0 nM, demonstrating varying potency. For antifungal activity, Decamethonium bromide inhibits Cryptococcus neoformans and Candida albicans with minimum inhibitory concentrations (MIC) of ≥350,000.0 nM and exhibits an IC50 value >250,000.0 nM against Cryptococcus neoformans H99 PLB1. Importantly, it shows no hemolytic activity at concentrations between 3.5 µM and 350 µM, indicating low cytotoxicity against human red blood cells. Additionally, this compound has inhibitory activity against acetylcholine esterase (IC50 = 1000.0 nM) and the human Jumonji Domain Containing 2E (JMJD2E), among other targets. It enhances SMN2 splice variant expression, acts as a general anesthetic, and inhibits several other biological interactions including the Menin-MLL interaction, human Apurinic/apyrimidinic Endonuclease 1 (APE1), and HP1-beta Chromodomain with methylated histone tails. Moreover, Decamethonium bromide demonstrates antiviral properties; it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells with modest activity and shows 9.222% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM. However, it does not significantly reduce cell viability in Vero E6 cells infected with SARS-CoV-2. Overall, Decamethonium bromide is characterized by its multifunctional bioactivity, including antimalarial, antifungal, antiviral, antitumor, and other pharmacological properties, making it a compound of significant interest for further research and development..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

Nicotinic acetylcholine receptorsnAChRInhibitorinhibitDecamethonium bromideDecamethoniumAChE
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