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Anethole trithione

Name: Anethole trithione
Brand: TargetMol
SKU: T1285
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.65%

货号 T1285Cas号 532-11-6

别名 茴三硫, Anetholtrithion

Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。

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Anethole trithione

一键复制产品信息

很棒

纯度: 99.65%

货号 T1285 别名 茴三硫, AnetholtrithionCas号 532-11-6

Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。

规格	价格	库存
10 mg	¥ 166	现货
25 mg	¥ 248	现货
50 mg	¥ 349	现货
100 mg	¥ 498	现货
500 mg	¥ 758	现货
1 g	¥ 1,090	现货
1 mL x 10 mM (in DMSO)	¥ 133	现货

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产品介绍

Anethole trithione AI Summary

Anethole trithione shows a moderate to high partition coefficient (logP = 3.82), suggesting good membrane permeability. It demonstrates increased quinone reductase (Log CDQR = 1.255) and growth hormone production (Log CDGH = 1.0), indicating potential antioxidant and growth-promoting activities. The compound exhibits hepatoprotective effects in Kunming mice by reducing CCL4-induced serum ALT and AST levels at doses of 1 mg/kg, 2 mg/kg, and 4 mg/kg when administered intraperitoneally. Despite its low aqueous solubility (<10.0 µg/mL), Anethole trithione is a potent inhibitor in various assays, targeting interactions like Menin-MLL, ROR gamma transcriptional activity, HDAC6, Histone Lysine Methyltransferase G9a, and more, with inhibitory concentrations ranging from nanomolar to micromolar levels. Anethole trithione exhibits significant antiviral activity, notably against SARS-CoV-2. It inhibits cytotoxicity in VERO-6 cells and Caco-2 cells at 10 µM concentrations after 48 hours, with variable inhibition rates. Despite lower hit scores in certain assays, it shows some inhibition of the SARS-CoV-2 3CL-Pro protease and a relatively weak potency in inhibiting cytotoxicity (IC50 > 20000.0 nM). Additionally, Anethole trithione displays bioactivity relevant to drug metabolism in mouse models, affecting plasma and liver metabolism by releasing hydrogen sulfide. It is also noted for its activity against Trypanosoma cruzi TIM enzyme with an IC50 of 1200.0 nM. Overall, Anethole trithione interacts with multiple receptors, exhibiting both agonist and antagonist activities across various pathways and influencing enzyme activities, showcasing its multifaceted potential in biomedicine..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.
别名	茴三硫, Anetholtrithion

化学信息

分子量	240.36
分子式	C₁₀H₈OS₃
CAS No.	532-11-6
Smiles	S=C1C=C(SS1)C2=CC=C(OC)C=C2
密度	1.4406 g/cm3 (Estimated)
颜色	orange
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (208.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.32 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1604 mL	20.8021 mL	41.6043 mL	208.0213 mL
5 mM	0.8321 mL	4.1604 mL	8.3209 mL	41.6043 mL
10 mM	0.4160 mL	2.0802 mL	4.1604 mL	20.8021 mL
20 mM	0.2080 mL	1.0401 mL	2.0802 mL	10.4011 mL
50 mM	0.0832 mL	0.4160 mL	0.8321 mL	4.1604 mL
100 mM	0.0416 mL	0.2080 mL	0.4160 mL	2.0802 mL