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Medroxyprogesterone

Name: Medroxyprogesterone
Brand: TargetMol
SKU: T5040
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.51%

货号 T5040Cas号 520-85-4

别名 甲孕酮, 甲羟孕酮

Medroxyprogesterone 是一种合成的人孕酮变体，是孕酮受体激动剂，用于治疗肾癌。在兽医实践中用作发情调节剂。

Medroxyprogesterone

一键复制产品信息

很棒

纯度: 99.51%

货号 T5040 别名 甲孕酮, 甲羟孕酮Cas号 520-85-4

Medroxyprogesterone 是一种合成的人孕酮变体，是孕酮受体激动剂，用于治疗肾癌。在兽医实践中用作发情调节剂。

规格	价格	库存
10 mg	¥ 166	现货
25 mg	¥ 248	现货
50 mg	¥ 349	现货
100 mg	¥ 498	现货
500 mg	¥ 1,490	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.51%

颜色: 白色

性状: Solid

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资源下载:

COA HPLC HNMR LCMS 产品操作手册

产品介绍

Medroxyprogesterone AI Summary

Medroxyprogesterone exhibits a diverse range of bioactivities, including significant effects on human MRP2-mediated transport with an activity level of 111.0%. The compound demonstrates inhibitory potency against various targets, such as Tau fibril formation, malaria parasite plastid function, and several viruses including Ebola, Lassa, Hepatitis C, and Foot and Mouth Disease virus. It notably inhibits CYP450 2C19 enzyme, glucocorticoid, androgen, and progesterone receptor binding, indicating its potential as an enzyme inhibitor and ligand binder. In terms of hepatotoxicity, Medroxyprogesterone shows moderate to severe liver toxicity with potential manifestations like elevated serum enzyme levels, severe clinical signs, cytolytic and cholestatic liver toxicity, severe hepatitis, hepatomegaly, and granulomatous liver disease, along with a combined hepatotoxic DILIps score of 5.0. Specific liver injury induction severity is classified at 2.0. The compound further indicates differential effects on cell viability, maintaining growth in HEK293T and U2OS cells but showing no growth in human fibroblast cells. It has varied antifungal and antibacterial activity, with moderate effects against Pseudomonas aeruginosa and Acinetobacter baumannii. In the context of antiviral activities, Medroxyprogesterone inhibits SARS-CoV-2 in HRCE cells, exhibits 7.702% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM, and shows mild inhibition of virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Additionally, it affects thermal stability of various protein domains and demonstrates an HDAC6 inhibition potential and a volume of distribution at steady state of Vdss = 4.66 L.kg-1, with a high fraction unbound in human plasma (logFu = 0.1)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
别名	甲孕酮, 甲羟孕酮

化学信息

分子量	344.49
分子式	C₂₂H₃₂O₃
CAS No.	520-85-4
Smiles	[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C
密度	1.13g/cm3

储存&溶解度

存储

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 71.43 mg/mL (207.35 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9028 mL	14.5142 mL	29.0284 mL	145.1421 mL
5 mM	0.5806 mL	2.9028 mL	5.8057 mL	29.0284 mL
10 mM	0.2903 mL	1.4514 mL	2.9028 mL	14.5142 mL
20 mM	0.1451 mL	0.7257 mL	1.4514 mL	7.2571 mL
50 mM	0.0581 mL	0.2903 mL	0.5806 mL	2.9028 mL
100 mM	0.0290 mL	0.1451 mL	0.2903 mL	1.4514 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

U-8840 U8840 U 8840 progestogenReceptor progestogen Receptor ProgesteroneReceptor Progesterone Receptor NR3C3 Medroxyprogesterone Inhibitor inhibit EstrogenReceptor Estrogen/progestogen Receptor Estrogen Receptor

Medroxyprogesterone

Medroxyprogesterone