购物车

您的购物车当前为空

Ketotifen fumarate

Name: Ketotifen fumarate
Brand: TargetMol
SKU: T0994
Price: 178 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.73%

货号 T0994Cas号 34580-14-8

别名 富马酸酮替芬, HC 20511 fumarate

Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。

Ketotifen fumarate

一键复制产品信息

很棒

纯度: 99.73%

货号 T0994 别名 富马酸酮替芬, HC 20511 fumarateCas号 34580-14-8

Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。

规格	价格	库存
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 455	现货
1 g	¥ 587	现货
2 g	¥ 859	现货
1 mL x 10 mM (in DMSO)	¥ 272	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.73%

颜色: 白色

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ketotifen fumarate AI Summary

Ketotifen fumarate demonstrates a broad spectrum of bioactivities, positioning it as a multifaceted compound with potential applications across various biological systems. It significantly inhibits degranulation in anti-DNP IgE sensitized rat RBL2H3 cells by reducing beta-hexosaminidase release after 10 minutes, exhibiting IC50 values of 220,000 nM and 158,000 nM. Additionally, it shows strong inhibitory activity at histamine H1 receptors in ddY mice, reducing histamine-induced skin vascular permeability by 98.0% at 3 mg/kg, and displays anti-inflammatory effects in BALB/c mice by inhibiting ovalbumin-induced ear swelling. Ketotifen fumarate also exhibits substantial antiplasmodial activity against Plasmodium falciparum, with IC50 values ranging from 794.33 nM to 10000.0 nM, and differential potency in various qHTS assays for inhibitors of proliferation of multiple Plasmodium falciparum lines. In terms of transport proteins, Ketotifen fumarate has high inhibitory activity in OATP1B1 and OATP1B3 transfected CHO cells. It shows antianaphylactic activity, inhibiting antigen-induced histamine release and slow-reacting substance of anaphylaxis in ovalbumin-sensitized guinea pig lung. Furthermore, it displays inhibition activity against SARS-CoV-2 by inhibiting viral-induced cytotoxicity in Vero E6 and Caco-2 cells and inhibiting 3CL-Pro protease by 17.19% at 20 µM concentration. Antifungal and antibacterial assays reveal limited inhibition against Candida albicans, Cryptococcus neoformans, and various bacterial strains, with percentages ranging from minimal to 11.46%. Additionally, it affects protein domain stability and GPCR beta-arrestin recruitment assays, displaying both inhibitory and stimulating effects on multiple receptors, signifying a complex pharmacological profile. Overall, Ketotifen fumarate is a compound of significant interest due to its wide-ranging bioactivities, implicating its potential in antiallergic, anti-inflammatory, antiplasmodial, antiviral, and possibly antifungal and antibacterial therapeutics..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
别名	富马酸酮替芬, HC 20511 fumarate

化学信息

分子量	425.50
分子式	C₂₃H₂₃NO₅S
CAS No.	34580-14-8
Smiles	OC(=O)\C=C\C(O)=O.CN1CC\C(CC1)=C1/c2ccsc2C(=O)Cc2ccccc12
密度	1.236g/cm3

储存&溶解度

存储

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 142.8 mg/mL (335.61 mM), Sonication is recommended.

H2O: 10.7 mg/mL (25.15 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3502 mL	11.7509 mL	23.5018 mL	117.5088 mL
5 mM	0.4700 mL	2.3502 mL	4.7004 mL	23.5018 mL
10 mM	0.2350 mL	1.1751 mL	2.3502 mL	11.7509 mL
20 mM	0.1175 mL	0.5875 mL	1.1751 mL	5.8754 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3502 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Ketotifen fumarate

Ketotifen fumarate

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Ketotifen fumarate

Ketotifen fumarate