Acridone

Name: Acridone
Brand: TargetMol
SKU: T20003
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.84%

货号 T20003Cas号 578-95-0

别名 吖啶酮

Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。

Acridone

一键复制产品信息

很棒

纯度: 99.84%

货号 T20003 别名 吖啶酮Cas号 578-95-0

Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。

规格	价格	库存	数量
5 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.84%

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产品介绍

Acridone AI Summary

Acridone exhibits a wide range of bioactivities and moderate lipophilicity, with a logP value of 2.975. This compound demonstrates moderate fluorescence quenching of ethidium bound to [(poly dG-dC)]2 DNA and moderate cytotoxic potency against CH1 cells (IC50 of 77000.0 nM). In various other cell lines, its cytotoxic potency has IC50 values greater than 100000.0 nM. It shows antiproliferative activity against human CCRF-CEM and HaCaT cells, both with IC50 values greater than 100000.0 nM and 50000.0 nM, respectively. Acridone is involved in inhibiting and activating multiple proteins and pathways, including Lamin A splicing, Jumonji Domain Containing 2E, and Human alpha-Glucosidase. This compound also reveals cytotoxic effects in DNA re-replication assays for normal breast cells and colon adenocarcinoma cells, and displays inhibition against Hepatitis C Virus (HCV) and ATXN expression assays. Additionally, it demonstrates significant activity against luciferase/luciferin-expressing antifolate-resistant parasites infecting HepG2 cells with IC50 values of 1.57 uM and CC50 value of 1.57 uM. Acridone binds to heme (Ka of 2.4 x 10^4/M) and inhibits heme-mediated bovine serum albumin oxidation (IC50 of 55000.0 nM), indicating its potential multi-target bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.
别名	吖啶酮

化学信息

分子量	195.22
分子式	C₁₃H₉NO
CAS No.	578-95-0
Smiles	O=c1c2ccccc2[nH]c2ccccc12
密度	1.23 g/cm3
颜色	Green
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (332.96 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (12.81 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1224 mL	25.6121 mL	51.2243 mL	256.1213 mL
5 mM	1.0245 mL	5.1224 mL	10.2449 mL	51.2243 mL
10 mM	0.5122 mL	2.5612 mL	5.1224 mL	25.6121 mL
20 mM	0.2561 mL	1.2806 mL	2.5612 mL	12.8061 mL
50 mM	0.1024 mL	0.5122 mL	1.0245 mL	5.1224 mL
100 mM	0.0512 mL	0.2561 mL	0.5122 mL	2.5612 mL